AKR1C2: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. Defects in AKR1C2 are a cause of 46,XY sex reversal type 8 (SRXY8). A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. Belongs to the aldo/keto reductase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.3.1.20; Oxidoreductase; EC 1.1.1.357; Xenobiotic Metabolism - metabolism by cytochrome P450
Cellular Component: cytoplasm; cytosol
Molecular Function: mevaldate reductase activity; bile acid binding; oxidoreductase activity; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; phenanthrene 9,10-monooxygenase activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; (R)-2-hydroxyisocaproate dehydrogenase activity; steroid dehydrogenase activity; carboxylic acid binding; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; D-arabinitol dehydrogenase (NADP+) activity; aldehyde reductase activity; acetoin dehydrogenase activity; gluconate dehydrogenase activity; (R)-2-hydroxyglutarate dehydrogenase activity; phenylcoumaran benzylic ether reductase activity; aldo-keto reductase activity; arabinose reductase activity; isocitrate dehydrogenase activity; epoxide dehydrogenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; ketosteroid monooxygenase activity; 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity; 3-ketoglucose-reductase activity; steroid dehydrogenase activity, acting on the CH-CH group of donors; 2-hydroxytetrahydrofuran dehydrogenase activity; 5-exo-hydroxycamphor dehydrogenase activity; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; xylose reductase activity
Biological Process: steroid metabolic process; lipid metabolic process; steroid biosynthetic process
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