Human RNASEH1 Recombinant Protein – Cat# MBS1023898

Ribonuclease H1 (RNASEH1) Human Recombinant Protein

Name: RNASEH1 Recombinant Protein; Ribonuclease H1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1023898
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1023898

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A)… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ribonuclease H1 (RNASEH1), Recombinant Protein

Full Product Name

Recombinant Human Ribonuclease H1 (RNASEH1)

Product Gene Name

RNASEH1 recombinant protein

Sequence

MSWLLFLAHR VALAALPCRR GSRGFGMFYA VRRGRKTGVF LTWNECRAQV DRFPAARFKK FATEDEAWAF VRKSASPEVS EGHENQHGQE SEAKASKRLR EPLDGDGHES AEPYAKHMKP SVEPAPPVSR DTFSYMGDFV VVYTDGCCSS NGRRRPRAGI GVYWGPGHPL NVGIRLPGRQ TNQRAEIHAA CKAIEQAKTQ NINKLVLYTD SMFTINGITN WVQGWKKNGW KTSAGKEVIN KEDFVALERL TQGMDIQWMH VPGHSGFIGN EEADRLAREG AKQSED

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

37.6 kDa

Sequence Positions

1-286. Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

604123

3D Structure

ModBase 3D Structure for O60930

Species

Homo sapiens (Human)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for RNASEH1 recombinant protein

Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for RNASEH1 recombinant protein

"Human senataxin resolves RNA DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination." Skourti-Stathaki K., Proudfoot N.J., Gromak N. Mol. Cell 42:794-805(2011)

Other Notes

Small volumes of RNASEH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RNASEH1 purchase

MBS1023898 is a recombinant protein targeting RNASEH1. Also known as Recombinant Human Ribonuclease H1 (RNASEH1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RNASEH1. It may not necessarily be applicable to this product.

NCBI GI #

21359816

NCBI GeneID

246243

NCBI Accession #

NP_002927.2

UniProt Primary Accession #

O60930

UniProt Secondary Accession #

O60523; O60857; Q57Z93; Q5U0C1; Q6FHD4; B3KQU4

UniProt Related Accession #

O60930

GenBank Nucleotide #

NM_002936.5

NCBI Official Full Name

ribonuclease H1 isoform 1

NCBI Official Synonym Full Names

ribonuclease H1

NCBI Official Symbol

RNASEH1

NCBI Official Synonym Symbols

RNH1; H1RNA; PEOB2

UniProt Protein Name

Ribonuclease H1

UniProt Synonym Protein Names

Ribonuclease H type II

Protein Family

Ribonuclease

UniProt Gene Name

RNASEH1

UniProt Synonym Gene Names

RNH1; RNase H1

NCBI Protein Information

ribonuclease H1

NCBI Summary for RNASEH1

This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017]

UniProt Comments for RNASEH1

Research Articles on RNASEH1

1. Studies indicate that ribonuclease H1 is essential for mitochondrial DNA replication.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RNASEH1 recombinant protein

Products by Pathway	Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram

Diseases associated with RNASEH1 recombinant protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>1 publications with RNASEH1 and Congenital Abnormalities
Nervous System Diseases Antibodies	>1 publications with RNASEH1 and Nervous System Diseases
Nervous System Malformations Antibodies	>1 publications with RNASEH1 and Nervous System Malformations

Organs/Tissues associated with RNASEH1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with RNASEH1 and Blood
Liver Antibodies	>1 publications with RNASEH1 and Liver