RNA-Binding Motif Protein, Y Chromosome, Family 1 Member A1 (RBMY1A1) Human Recombinant Protein

RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.

A Y chromosome gene family with RNA-binding protein homology candidates for the azoospermia factor AZF controlling human spermatogenesis.Ma K., Inglis J.D., Sharkey A., Bickmore W.A., Hill R.E., Prosser E.J., Speedson R.M., Thomson E.J., Jobling M.Cell 75:1287-1295(1993) The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C.Nature 423:825-837(2003) Structure and organization of the RBMY genes on the human Y chromosome transposition and amplification of an ancestral autosomal hnRNPG gene.Chai N.-N., Zhou H., Hernandez J., Najmabadi H., Bhasin S., Yen P.H.Genomics 49:283-289(1998) Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm.Elliott D.J., Millar M.R., Oghene K., Ross A., Kiesewetter F., Pryor J., McIntyre M., Hargreave T.B., Saunders P.T.K., Vogt P.H., Chandley A.C., Cooke H.Proc. Natl. Acad. Sci. U.S.A. 94:3848-3853(1997) T-STAR/ETOILE a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.Venables J.P., Vernet C., Chew S.L., Elliott D.J., Cowmeadow R.B., Wu J., Cooke H.J., Artzt K., Eperon I.C.Hum. Mol. Genet. 8:959-969(1999) RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.Venables J.P., Elliott D.J., Makarova O.V., Makarov E.M., Cooke H.J., Eperon E.C.Hum. Mol. Genet. 9:685-694(2000) hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1.Hofmann Y., Wirth B.Hum. Mol. Genet. 11:2037-2049(2002) The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.Elliott D.J.Int. J. Androl. 27:328-334(2004) The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction.Skrisovska L., Bourgeois C.F., Stefl R., Grellscheid S.-N., Kister L., Wenter P., Elliott D.J., Stevenin J., Allain F.H.-T.EMBO Rep. 8:372-379(2007)

Small volumes of RBMY1A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1029535 is a recombinant protein targeting RBMY1A1. Also known as Recombinant Human RNA-binding motif protein, Y chromosome, family 1 member A1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.