Human RASGRP1 Recombinant Protein – Cat# MBS1038776

RAS Guanyl-Releasing Protein 1 (RASGRP1) Human Recombinant Protein

Name: RASGRP1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1038776
Price: 1680 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1038776

$1680 / 0.02 mg (E-Coli) +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RAS guanyl-releasing protein 1 (RASGRP1), Recombinant Protein

Full Product Name

Recombinant Human RAS guanyl-releasing protein 1 (RASGRP1)

Product Gene Name

RASGRP1 recombinant protein

Sequence

MGTLGKAREA PRKPSHGCRA ASKARLEAKP ANSPFPSHPS LAHITQFRMM VSLGHLAKGA SLDDLIDSCI QSFDADGNLC RSNQLLQVML TMHRIVISSA ELLQKVITLY KDALAKNSPG LCLKICYFVR YWITEFWVMF KMDASLTDTM EEFQELVKAK GEELHCRLID TTQINARDWS RKLTQRIKSN TSKKRKVSLL FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE NPTMERSIAL CNGISQWVQL MVLSRPTPQL RAEVFIKFIQ VAQKLHQLQN FNTLMAVIGG LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSSRNYDNY RRAYGECTDF KIPILGVHLK DLISLYEAMP DYLEDGKVNV HKLLALYNHI SELVQLQEVA PPLEANKDLV HLLTLSLDLY YTEDEIYELS YAREPRNHRA PPLTPSKPPV VVDWASGVSP KPDPKTISKH VQRMVDSVFK NYDHDQDGYI SQEEFEKIAA SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF PHNFQETTYL KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRAKNPVA PTENNTSVGP VSNLCSLGAK DLLHAPEEGP FTFPNGEAVE HGEESKDRTI MLMGVSSQKI SLRLKRAVAH KATQTESQPW IGSEGPSGPF VLSSPRKTAQ DTLYVLPSPT SPCPSPVLVR KRAFVKWENK DSLIKSKEEL RHLRLPTYQE LEQEINTLKA DNDALKIQLK YAQKKIESLQ LEKSNHVLAQ MEQGDCS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

62,674 Da

Sequence Positions

1-797, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

152700

3D Structure

ModBase 3D Structure for O95267

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RASGRP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RASGRP1 purchase

MBS1038776 is a recombinant protein targeting RASGRP1. Also known as Recombinant Human RAS guanyl-releasing protein 1 (RASGRP1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RASGRP1. It may not necessarily be applicable to this product.

NCBI GI #

190684646

NCBI GeneID

10125

NCBI Accession #

NP_001122074.1

UniProt Primary Accession #

O95267

UniProt Secondary Accession #

Q56CZ0; Q58G75; Q59HB1; Q5I3A8; Q6GV31; Q6NX39; Q7LDG6; Q9UI94; Q9UNN9

UniProt Related Accession #

O95267

GenBank Nucleotide #

NM_001128602.1

NCBI Official Full Name

RAS guanyl-releasing protein 1 isoform b

NCBI Official Synonym Full Names

RAS guanyl releasing protein 1

NCBI Official Symbol

RASGRP1

NCBI Official Synonym Symbols

V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII

UniProt Protein Name

RAS guanyl-releasing protein 1

UniProt Synonym Protein Names

Calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; Ras guanyl-releasing protein

Protein Family

RAS guanyl-releasing protein

UniProt Gene Name

RASGRP1

UniProt Synonym Gene Names

RASGRP; CalDAG-GEFII

NCBI Protein Information

RAS guanyl-releasing protein 1

NCBI Summary for RASGRP1

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

UniProt Comments for RASGRP1

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (). May also function in differentiation of other cell types (PubMed:12845332).

Research Articles on RASGRP1

1. The marked differences between RasGRP3 and RasGRP1 in membrane interaction necessarily will contribute to their different behavior in cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RASGRP1 recombinant protein

Reference Product	PubMed Publications
HRAS recombinant protein	>1 publications with RASGRP1 and HRAS

Pathways associated with RASGRP1 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of RAS In B Cells Pathway antibodies	Activation Of RAS In B Cells Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Effects Of PIP2 Hydrolysis Pathway antibodies	Effects Of PIP2 Hydrolysis Pathway Diagram
FCERI Mediated NF-kB Activation Pathway antibodies	FCERI Mediated NF-kB Activation Pathway Diagram
Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies	Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with RASGRP1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>23 publications with RASGRP1 and Neoplasms
Leukemia, Myeloid, Acute Antibodies	>6 publications with RASGRP1 and Leukemia, Myeloid, Acute
Necrosis Antibodies	>4 publications with RASGRP1 and Necrosis
Neoplasms, Experimental Antibodies	>3 publications with RASGRP1 and Neoplasms, Experimental
Nervous System Diseases Antibodies	>3 publications with RASGRP1 and Nervous System Diseases
Edema Antibodies	>1 publications with RASGRP1 and Edema
Liver Diseases Antibodies	>1 publications with RASGRP1 and Liver Diseases
Inflammation Antibodies	>1 publications with RASGRP1 and Inflammation
Drug-Induced Liver Injury Antibodies	>1 publications with RASGRP1 and Drug-Induced Liver Injury
Breast Neoplasms Antibodies	>1 publications with RASGRP1 and Breast Neoplasms

Organs/Tissues associated with RASGRP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>78 publications with RASGRP1 and Blood
Brain Antibodies	>18 publications with RASGRP1 and Brain
Thymus Antibodies	>15 publications with RASGRP1 and Thymus
Spleen Antibodies	>6 publications with RASGRP1 and Spleen
Kidney Antibodies	>5 publications with RASGRP1 and Kidney
Eye Antibodies	>2 publications with RASGRP1 and Eye
Liver Antibodies	>2 publications with RASGRP1 and Liver
Muscle Antibodies	>1 publications with RASGRP1 and Muscle
Pancreas Antibodies	>1 publications with RASGRP1 and Pancreas
Ovary Antibodies	>1 publications with RASGRP1 and Ovary