Rat ADORA2B Recombinant Protein – Cat# MBS1062507

Adenosine Receptor A2b (ADORA2B) Rat Recombinant Protein

Name: ADORA2B Recombinant Protein; Adenosine Receptor A2b; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS1062507
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1062507

MBS1062507 is a recombinant protein targeting Adora2b. Also known as Recombinant Rat Adenosine receptor A2b (Adora2b). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Adora2b More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Adenosine receptor A2b (Adora2b), Recombinant Protein

Full Product Name

Recombinant Rat Adenosine receptor A2b (Adora2b)

Product Gene Name

Adora2b recombinant protein

Product Synonym Gene Name

Recombinant Adenosine receptor A2b (Adora2b); Adenosine receptor A2b

Sequence

MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA TADVAVGLFA IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDRA TSNCTEPGDG ITNKSCCPVK CLFENVVPMS YMVYFNFFGC VLPPLLIMMV IYIKIFMVAC KQLQHMELME HSRTTLQREI HAAKSLAMIV GIFALCWLPV HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS FHRIISRYVL CQTDTKGGSG QAGGQSTFSL SL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

36,367 Da

Sequence Positions

1-332

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 10; NC_005109.3 (48358068..48374871). Location: 10q23

3D Structure

ModBase 3D Structure for P29276

Species

Rattus norvegicus (Rat)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Adora2b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Adora2b. It may not necessarily be applicable to this product.

NCBI GI #

8392864

NCBI GeneID

29316

NCBI Accession #

NP_058857.1

UniProt Primary Accession #

P29276

UniProt Related Accession #

P29276

GenBank Nucleotide #

NM_017161.1

NCBI Official Full Name

adenosine receptor A2b

NCBI Official Synonym Full Names

adenosine A2B receptor

NCBI Official Symbol

Adora2b

UniProt Protein Name

Adenosine receptor A2b

Protein Family

Adenosine receptor

UniProt Gene Name

Adora2b

UniProt Entry Name

AA2BR_RAT

NCBI Protein Information

adenosine receptor A2b

NCBI Summary for Adora2b

regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury [RGD, Feb 2006]

UniProt Comments for Adora2b

ADORA2B: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; adenosine receptor activity, G-protein coupled

Biological Process: relaxation of vascular smooth muscle; negative regulation of collagen biosynthetic process; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of guanylate cyclase activity; positive regulation of vasodilation; G-protein signaling, adenylate cyclase activating pathway; regulation of angiogenesis; positive regulation of chemokine production; negative regulation of cell proliferation; positive regulation of cGMP biosynthetic process; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; positive regulation of chronic inflammatory response to non-antigenic stimulus; cellular response to extracellular stimulus; positive regulation of catecholamine secretion; adenosine receptor signaling pathway

Research Articles on Adora2b

1. 2',3'-cAMP inhibits proliferation of vascular smooth muscle cells from the aorta and coronary arteries. This effect is due in part to metabolism of 2',3'-cAMP to adenosine, with engagement of the A2B receptor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Adora2b recombinant protein

Reference Product	PubMed Publications
Adora2a recombinant protein	>16 publications with Adora2b and Adora2a

Pathways associated with Adora2b recombinant protein

Products by Pathway	Pathway Diagram
Adenosine P1 Receptors Pathway antibodies	Adenosine P1 Receptors Pathway Diagram
Alcoholism Pathway antibodies	Alcoholism Pathway Diagram
Alcoholism Pathway antibodies	Alcoholism Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with Adora2b recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>14 publications with Adora2b and Inflammation
Nervous System Diseases Antibodies	>5 publications with Adora2b and Nervous System Diseases
Cardiovascular Diseases Antibodies	>5 publications with Adora2b and Cardiovascular Diseases
Disease Models, Animal Antibodies	>3 publications with Adora2b and Disease Models, Animal
Hypertension Antibodies	>3 publications with Adora2b and Hypertension
Neoplasms Antibodies	>3 publications with Adora2b and Neoplasms
Kidney Diseases Antibodies	>2 publications with Adora2b and Kidney Diseases
Necrosis Antibodies	>2 publications with Adora2b and Necrosis
Drug Toxicity Antibodies	>2 publications with Adora2b and Drug Toxicity
Breast Neoplasms Antibodies	>1 publications with Adora2b and Breast Neoplasms

Organs/Tissues associated with Adora2b recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>5 publications with Adora2b and Lung
Kidney Antibodies	>4 publications with Adora2b and Kidney
Placenta Antibodies	>1 publications with Adora2b and Placenta