Bovine MMP13 Recombinant Protein – Cat# MBS1082772

Collagenase 3 (MMP13) Bovine Recombinant Protein

Name: MMP13 Recombinant Protein; Collagenase 3; Bovine; MyBioSource
Brand: MyBioSource
SKU: MBS1082772
Price: 1090 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1082772

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as… More details

$1090 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Collagenase 3 (MMP13), Recombinant Protein

Full Product Name

Recombinant Bovine Collagenase 3 (MMP13)

Product Gene Name

MMP13 recombinant protein

Sequence

YNVFPRTLKW SKMNLTYRIV NYTPDLTHSE VEKAFRKAFK VWSDVTPLNF TRIHNGTADI MISFGTKEHG DFYPFDGPSG LLAHAFPPGP NYGGDAHFDD DETWTSSSKG YNLFLVAAHE FGHSLGLDHS KDPGALMFPI YTYTGKSHFM LPDDDVQGIQ SLYGPGDEDP YSKHPKTPDK CDPSLSLDAI TSLRGETLIF KDRFFWRLHP QQVEAELFLT KSFGPELPNR IDAAYEHPSH DLIFIFRGRK FWALSGYDIL EDYPKKISEL GFPKHVKKIS AALHFEDSGK TLFFSENQVW SYDDTNHVMD KDYPRLIEEV FPGIGDKVDA VYQKNGYIYF FNGPIQFEYS IWSNRIVRVM TTNSLLWC

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

53,921 Da

Sequence Positions

104-471, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O77656

Species

Bovine

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MMP13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP13 purchase

MBS1082772 is a recombinant protein targeting MMP13. Also known as Recombinant Bovine Collagenase 3 (MMP13). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP13. It may not necessarily be applicable to this product.

NCBI GI #

27805999

NCBI GeneID

281914

NCBI Accession #

NP_776814.1

UniProt Primary Accession #

O77656

UniProt Related Accession #

O77656

GenBank Nucleotide #

NM_174389.2

NCBI Official Full Name

collagenase 3

NCBI Official Synonym Full Names

matrix metallopeptidase 13

NCBI Official Symbol

MMP13

UniProt Protein Name

Collagenase 3

UniProt Synonym Protein Names

Matrix metalloproteinase-13; MMP-13

Protein Family

Collagenase

UniProt Gene Name

MMP13

UniProt Synonym Gene Names

MMP-13

NCBI Protein Information

collagenase 3

UniProt Comments for MMP13

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion ().

Research Articles on MMP13

1. p38 phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP13 recombinant protein

Reference Product	PubMed Publications
MMP-3 recombinant protein	>214 publications with MMP13 and MMP-3
TIMP1 recombinant protein	>75 publications with MMP13 and TIMP1
MMP14 recombinant protein	>58 publications with MMP13 and MMP14
TIMP2 recombinant protein	>32 publications with MMP13 and TIMP2
CTSK recombinant protein	>13 publications with MMP13 and CTSK
LAMB3 recombinant protein	>2 publications with MMP13 and LAMB3
COL18A1 recombinant protein	>2 publications with MMP13 and COL18A1
HSPG2 recombinant protein	>1 publications with MMP13 and HSPG2

Pathways associated with MMP13 recombinant protein

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram

Diseases associated with MMP13 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>261 publications with MMP13 and Inflammation
Disease Models, Animal Antibodies	>211 publications with MMP13 and Disease Models, Animal
Necrosis Antibodies	>185 publications with MMP13 and Necrosis
Fibrosis Antibodies	>120 publications with MMP13 and Fibrosis
Neoplasm Invasiveness Antibodies	>86 publications with MMP13 and Neoplasm Invasiveness
Liver Diseases Antibodies	>79 publications with MMP13 and Liver Diseases
Hypertrophy Antibodies	>78 publications with MMP13 and Hypertrophy
Breast Neoplasms Antibodies	>58 publications with MMP13 and Breast Neoplasms
Pain Antibodies	>39 publications with MMP13 and Pain
Heart Diseases Antibodies	>34 publications with MMP13 and Heart Diseases

Organs/Tissues associated with MMP13 recombinant protein

Organ/Tissue Name	Pubmed Publications
Mammary Gland Antibodies	>5 publications with MMP13 and Mammary Gland