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FDFT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9211522

FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the… More details

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Product Overview

Online Datasheet in PDF
Product Name
FDFT1, Polyclonal Antibody
Full Product Name
FDFT1 Antibody (N-term)
Product Gene Name
anti-FDFT1 antibody
Product Synonym Names
Squalene synthase; SQS; SS; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT1
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 2 (lot specific)
Specificity
This FDFT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FDFT1.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
FDFT1 peptide (MBS9224668) is used for blocking the activity of FDFT1 antibody (MBS9211522)
Molecular Weight
48115
Immunogen Sequence Positions
1-30
OMIM
184420
3D Structure
ModBase 3D Structure for P37268
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-FDFT1 antibody

Cancer; Cardiovascular; Metabolism; Neuroscience
Applications Tested/Suitable for anti-FDFT1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-FDFT1 antibody
WB~~1:1000

Western Blot (WB) of anti-FDFT1 antibody

The anti-FDFT1 Pab is used in Western blot to detect FDFT1 in mouse cerebellum tissue lysate.
Rabbit Anti-FDFT1 Polyclonal Antibody – Cat# MBS9211522

Western Blot (WB) of anti-FDFT1 antibody

Western blot analysis of FDFT1 (arrow) using rabbit polyclonal FDFT1 Antibody (E11). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDFT1 gene.
Rabbit Anti-FDFT1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9211522

Immunohistochemistry (IHC) of anti-FDFT1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-FDFT1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9211522

Product References and Citations for anti-FDFT1 antibody

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Soltis, D.A., et al., Arch. Biochem. Biophys. 316(2):713-723 (1995).
Jiang, G., et al., J. Biol. Chem. 268(17):12818-12824 (1993).
Robinson, G.W., et al., Mol. Cell. Biol. 13(5):2706-2717 (1993).
Summers, C., et al., Gene 136 (1-2Che), 185-192 (1993).

Other Notes

Small volumes of anti-FDFT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FDFT1 purchase

MBS9211522 is an antibody targeting FDFT1. Also known as FDFT1 Antibody (N-term). Reactive in Human, mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FDFT1. It may not necessarily be applicable to this product.

NCBI GI #
67089147
NCBI GeneID
2222
NCBI Accession #
NP_004453.3
UniProt Primary Accession #
P37268
UniProt Secondary Accession #
Q96GT0; B3KQ95; B4DJE5; B4DT56; B7Z1J3
UniProt Related Accession #
P37268
GenBank Nucleotide #
NM_004462.4
NCBI Official Full Name
squalene synthase isoform 1
NCBI Official Synonym Full Names
farnesyl-diphosphate farnesyltransferase 1
NCBI Official Symbol
FDFT1
NCBI Official Synonym Symbols
SS; SQS; DGPT; ERG9
UniProt Protein Name
Squalene synthase
UniProt Synonym Protein Names
FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase
UniProt Gene Name
FDFT1
UniProt Synonym Gene Names
SQS; SS
UniProt Entry Name
FDFT_HUMAN
NCBI Protein Information
squalene synthase

NCBI Summary for FDFT1

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FDFT1

FDFT1: a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]

Protein type: Transferase; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; EC 2.5.1.21

Chromosomal Location of Human Ortholog: 8p23.1-p22

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: farnesyl-diphosphate farnesyltransferase activity; oxidoreductase activity

Biological Process: isoprenoid biosynthetic process; farnesyl diphosphate metabolic process; cellular lipid metabolic process; cholesterol biosynthetic process; steroid biosynthetic process
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Research Articles on FDFT1

1. Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-alpha receptor 1 and nuclear factor-kappaB activation and matrix metallopeptidase 1 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FDFT1 antibody

 Reference Product  PubMed Publications
 LSS antibody  >6 publications with FDFT1 and LSS
 SQLE antibody  >6 publications with FDFT1 and SQLE
 FDPS antibody  >5 publications with FDFT1 and FDPS
 HSD17B7 antibody  >1 publications with FDFT1 and HSD17B7
 MSMO1 antibody  >1 publications with FDFT1 and MSMO1

Pathways associated with anti-FDFT1 antibody

 Products by Pathway  Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram
 Flagellar Assembly Pathway antibodies  Flagellar Assembly Pathway Diagram

Diseases associated with anti-FDFT1 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >5 publications with FDFT1 and Fatty Liver
 Cardiovascular Diseases Antibodies  >5 publications with FDFT1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >3 publications with FDFT1 and Liver Diseases
 Nervous System Diseases Antibodies  >3 publications with FDFT1 and Nervous System Diseases
 Fibrosis Antibodies  >2 publications with FDFT1 and Fibrosis
 Inflammation Antibodies  >2 publications with FDFT1 and Inflammation
 Breast Neoplasms Antibodies  >1 publications with FDFT1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >1 publications with FDFT1 and Liver Neoplasms
 Phencyclidine Abuse Antibodies  >1 publications with FDFT1 and Phencyclidine Abuse
 Marijuana Abuse Antibodies  >1 publications with FDFT1 and Marijuana Abuse

Organs/Tissues associated with anti-FDFT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >13 publications with FDFT1 and Liver
 Blood Antibodies  >7 publications with FDFT1 and Blood
 Brain Antibodies  >6 publications with FDFT1 and Brain
 Prostate Antibodies  >3 publications with FDFT1 and Prostate
 Heart Antibodies  >3 publications with FDFT1 and Heart
 Stomach Antibodies  >3 publications with FDFT1 and Stomach
 Eye Antibodies  >2 publications with FDFT1 and Eye
 Skin Antibodies  >2 publications with FDFT1 and Skin
 Muscle Antibodies  >1 publications with FDFT1 and Muscle
 Ovary Antibodies  >1 publications with FDFT1 and Ovary
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