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Galanin Receptor Type 2 (GALR2) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1083367

MBS1083367 is a recombinant protein targeting Galr2. Also known as Recombinant Rat Galanin receptor type 2 (Galr2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Galr2; Galnr2 More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Galanin receptor type 2 (Galr2), Recombinant Protein
Full Product Name
Recombinant Rat Galanin receptor type 2 (Galr2)
Product Gene Name
Galr2 recombinant protein
Product Synonym Gene Name
Recombinant Galanin receptor type 2 (Galr2); Galanin receptor type 2; GAL2-R; GALR-2
Sequence
MNGSGSQGAE NTSQEGGSGG WQPEAVLVPL FFALIFLVGT VGNALVLAVL LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDD WVFGSLLCKA VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW GLALLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDLC TFVFSYLLPV LVLSLTYART LRYLWRTVDP VTAGSGSQRA KRKVTRMIII VAVLFCLCWM PHHALILCVW FGRFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR KGFRKICAGL LRPAPRRASG RVSILAPGNH SGSMLEQEST DLTQVSEAAG PLVPPPALPN CTASSRTLDP AC
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
40,676 Da
Sequence Positions
1-372
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 10; NC_005109.3 (104900150..104902315). Location: 10q32.3
3D Structure
ModBase 3D Structure for O08726
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Galr2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Galr2. It may not necessarily be applicable to this product.

NCBI GI #
9506709
NCBI GeneID
29234
NCBI Accession #
NP_062045.1
UniProt Primary Accession #
O08726
UniProt Related Accession #
O08726
GenBank Nucleotide #
NM_019172.4
NCBI Official Full Name
galanin receptor type 2
NCBI Official Synonym Full Names
galanin receptor 2
NCBI Official Symbol
Galr2
UniProt Protein Name
Galanin receptor type 2
Protein Family
Galanin receptor
UniProt Gene Name
Galr2
UniProt Synonym Gene Names
Galnr2; GAL2-R; GALR-2
UniProt Entry Name
GALR2_RAT
NCBI Protein Information
galanin receptor type 2; GAL2-R; GALR-2

NCBI Summary for Galr2

mediates inositol phospholipid turnover and intracellular calcium levels; functions through the activation of phospholipase C [RGD, Feb 2006]

UniProt Comments for Galr2

GALR2: Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Cellular Component: integral to membrane; plasma membrane

Molecular Function: neuropeptide binding; peptide hormone binding; galanin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; inositol phosphate metabolic process; neuropeptide signaling pathway; negative regulation of adenylate cyclase activity; positive regulation of transcription from RNA polymerase II promoter; phosphatidylinositol metabolic process; G-protein signaling, adenylate cyclase activating pathway; neurite development
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Research Articles on Galr2

1. This study found that GALR2 mRNA was expressed in granulation tissue, including in pericytes, but only in pericytes that had been dissociated from endothelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Galr2 recombinant protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with Galr2 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >49 publications with Galr2 and Nervous System Diseases
 Neoplasms Antibodies  >18 publications with Galr2 and Neoplasms
 Seizures Antibodies  >17 publications with Galr2 and Seizures
 Disease Models, Animal Antibodies  >9 publications with Galr2 and Disease Models, Animal
 Obesity Antibodies  >6 publications with Galr2 and Obesity
 Nerve Degeneration Antibodies  >4 publications with Galr2 and Nerve Degeneration
 Learning Disorders Antibodies  >4 publications with Galr2 and Learning Disorders
 Weight Gain Antibodies  >4 publications with Galr2 and Weight Gain
 Skin Diseases Antibodies  >3 publications with Galr2 and Skin Diseases
 Breast Neoplasms Antibodies  >2 publications with Galr2 and Breast Neoplasms

Organs/Tissues associated with Galr2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >95 publications with Galr2 and Brain
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