Human LGMN cDNA Clone Expression Plasmid – Cat# MBS1272632

LGMN cDNA Clone – Legumain (Human)

Name: LGMN cDNA Clone; Legumain; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272632
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272632

MBS1272632 is a cDNA clone targeting LGMN. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LGMN, cDNA Clone

Full Product Name

LGMN cDNA Clone

Product Gene Name

LGMN cdna clone

Sequence

atggtttgga aagtagctgt attcctcagt gtggccctgg gcattggtgc cattcctata gatgatcctg aagatggagg caagcactgg gtggtgatcg tggcaggttc aaatggctgg tataattata ggcaccaggc agacgcgtgc catgcctacc agatcattca ccgcaatggg attcctgacg aacagatcgt tgtgatgatg tacgatgaca ttgcttactc tgaagacaat cccactccag gaattgtgat caacaggccc aatggcacag atgtctatca gggagtcccg aaggactaca ctggagagga tgttacccca caaaatttcc ttgctgtgtt gagaggcgat gcagaagcag tgaagggcat aggatccggc aaagtcctga agagtggccc ccaggatcac gtgttcattt acttcactga ccatggatct actggaatac tggtttttcc caatgaagat cttcatgtaa aggacctgaa tgagaccatc cattacatgt acaaacacaa aatgtaccga aagatggtgt tctacattga agcctgtgag tctgggtcca tgatgaacca cctgccggat aacatcaatg tttatgcaac tactgctgcc aaccccagag agtcgtccta cgcctgttac tatgatgaga agaggtccac gtacctgggg gactggtaca gcgtcaactg gatggaagac tcggacgtgg aagatctgac taaagagacc ctgcacaagc agtaccacct ggtaaaatcg cacaccaaca ccagccacgt catgcagtat ggaaacaaaa caatctccac catgaaagtg atgcagtttc agggtatgaa acgcaaagcc agttctcccg tccccctacc tccagtcaca caccttgacc tcacccccag ccctgatgtg cctctcacca tcatgaaaag gaaactgatg aacaccaatg atctggagga gtccaggcag ctcacggagg agatccagcg gcatctggat gccaggcacc tcattgagaa gtcagtgcgt aagatcgtct ccttgctggc agcgtccgag gctgaggtgg agcagctcct gtccgagaga gccccgctca cggggcacag ctgctaccca gaggccctgc tgcacttccg gacccactgc ttcaactggc actcccccac gtacgagtat gcgttgagac atttgtacgt gctggtcaac ctttgtgaga agccgtatcc acttcacagg ataaaattgt ccatggacca cgtgtgcctt ggtcactact ga

Molecular Weight

42,008 Da

OMIM

602620

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LGMN cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LGMN. It may not necessarily be applicable to this product.

NCBI GI #

33872604

NCBI GeneID

5641

NCBI Accession #

BC003061

UniProt Secondary Accession #

O00123; Q86TV2; Q86TV3; Q9BTY1

UniProt Related Accession #

Q99538

NCBI Official Full Name

Homo sapiens legumain, mRNA

NCBI Official Synonym Full Names

legumain

NCBI Official Symbol

LGMN

NCBI Official Synonym Symbols

AEP; LGMN1; PRSC1

UniProt Protein Name

Legumain

UniProt Synonym Protein Names

Asparaginyl endopeptidase; Protease, cysteine 1

UniProt Gene Name

LGMN

UniProt Synonym Gene Names

PRSC1

UniProt Entry Name

LGMN_HUMAN

NCBI Protein Information

legumain

NCBI Summary for LGMN

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

UniProt Comments for LGMN

LGMN: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Belongs to the peptidase C13 family.

Protein type: EC 3.4.22.34; Protease

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: lysosomal lumen; lysosome

Molecular Function: cysteine-type endopeptidase activity; peptidase activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of neuron apoptosis; proteolysis; proteolysis involved in cellular protein catabolic process; receptor catabolic process; renal system process; toll-like receptor signaling pathway; vacuolar protein processing; vitamin D metabolic process

Research Articles on LGMN

1. AEP acts as a delta-secretase, cleaving APP at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP. AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with LGMN cdna clone

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
MHC Class II Antigen Presentation Pathway antibodies	MHC Class II Antigen Presentation Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with LGMN cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with LGMN and Neoplasms
Liver Neoplasms Antibodies	>1 publications with LGMN and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>1 publications with LGMN and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>1 publications with LGMN and Liver Diseases

Organs/Tissues associated with LGMN cdna clone

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>2 publications with LGMN and Embryonic Tissue
Blood Antibodies	>2 publications with LGMN and Blood
Pancreas Antibodies	>1 publications with LGMN and Pancreas
Liver Antibodies	>1 publications with LGMN and Liver
Uterus Antibodies	>1 publications with LGMN and Uterus