Leukocyte Cell-Derived Chemotaxin 1 (LECT1) Rat Recombinant Protein

Function: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization

By similarity.

Subcellular location: Chondromodulin-1: Secreted

By similarity. Note: Accumulated in the inter-territorial matrix of cartilage

By similarity.Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein

Potential.

Tissue specificity: Detected in cartilage, cardiac valves and valvular interstitial cells (at protein level). Expressed in eye. Ref.2

Developmental stage: Expression first detected in heart at E9.5 and persisted in the adult. Ref.2

Post-translational modification: After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein

By similarity.

Sequence similarities: Belongs to the chondromodulin-1 family.Contains 1 BRICHOS domain.