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ATP-Dependent Clp Protease ATP-Binding Subunit Clpx-Like, Mitochondrial (CLPX) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1120976

MBS1120976 is a recombinant protein targeting CLPX. Also known as Recombinant Human ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1370 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX), Recombinant Protein
Full Product Name
Recombinant Human ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX)
Product Gene Name
CLPX recombinant protein
Sequence
FTETPAYFAS KDGISKDGSG DGNKKSASEG SSKKSGSGNS GKGGNQLRCP KCGDLCTHVE TFVSSTRFVK CEKCHHFFVV LSEADSKKSI IKEPESAAEA VKLAFQQKPP PPPKKIYNYL DKYVVGQSFA KKVLSVAVYN HYKRIYNNIP ANLRQQAEVE KQTSLTPREL EIRRREDEYR FTKLLQIAGI SPHGNALGAS MQQQVNQQIP QEKRGGEVLD SSHDDIKLEK SNILLLGPTG SGKTLLAQTL AKCLDVPFAI CDCTTLTQAG YVGEDIESVI AKLLQDANYN VEKAQQGIVF LDEVDKIGSV PGIHQLRDVG GEGVQQGLLK LLEGTIVNVP EKNSRKLRGE TVQVDTTNIL FVASGAFNGL DRIISRRKNE KYLGFGTPSN LGKGRRAAAA ADLANRSGES NTHQDIEEKD RLLRHVEARD LIEFGMIPEF VGRLPVVVPL HSLDEKTLVQ ILTEPRNAVI PQYQALFSMD KCELNVTEDA LKAIARLALE RKTGARGLRS IMEKLLLEPM FEVPNSDIVC VEVDKEVVEG KKEPGYIRAP TKESSEEEYD SGVEEEGWPR QADAANS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
69,224 Da
Sequence Positions
57-633, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
615611
3D Structure
ModBase 3D Structure for O76031
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CLPX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CLPX. It may not necessarily be applicable to this product.

NCBI GI #
7242140
NCBI GeneID
10845
NCBI Accession #
NP_006651.2
UniProt Primary Accession #
O76031
UniProt Secondary Accession #
Q9H4D9; A1L428; A8K8F1; B9EGI8
UniProt Related Accession #
O76031
GenBank Nucleotide #
NM_006660.4
NCBI Official Full Name
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
NCBI Official Synonym Full Names
caseinolytic mitochondrial matrix peptidase chaperone subunit
NCBI Official Symbol
CLPX
UniProt Protein Name
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Protein Family
ATP-dependent Clp protease ATP-binding
UniProt Gene Name
CLPX
NCBI Protein Information
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

NCBI Summary for CLPX

The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
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UniProt Comments for CLPX

ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689).
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Research Articles on CLPX

1. Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CLPX recombinant protein

 Reference Product  PubMed Publications
 CLPP recombinant protein  >167 publications with CLPX and CLPP

Diseases associated with CLPX recombinant protein

 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >6 publications with CLPX and Skin Diseases
 Lung Diseases Antibodies  >2 publications with CLPX and Lung Diseases
 Liver Diseases Antibodies  >2 publications with CLPX and Liver Diseases
 Confusion Antibodies  >1 publications with CLPX and Confusion
 Coma Antibodies  >1 publications with CLPX and Coma
 Kidney Diseases Antibodies  >1 publications with CLPX and Kidney Diseases
 Drug Hypersensitivity Antibodies  >1 publications with CLPX and Drug Hypersensitivity
 Drug Toxicity Antibodies  >1 publications with CLPX and Drug Toxicity
 Necrosis Antibodies  >1 publications with CLPX and Necrosis
 Cholestasis Antibodies  >1 publications with CLPX and Cholestasis

Organs/Tissues associated with CLPX recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >6 publications with CLPX and Skin
 Liver Antibodies  >5 publications with CLPX and Liver
 Blood Antibodies  >4 publications with CLPX and Blood
 Muscle Antibodies  >2 publications with CLPX and Muscle
 Lung Antibodies  >2 publications with CLPX and Lung
 Bone Antibodies  >1 publications with CLPX and Bone
 Spleen Antibodies  >1 publications with CLPX and Spleen
 Eye Antibodies  >1 publications with CLPX and Eye
 Heart Antibodies  >1 publications with CLPX and Heart
 Lymph Node Antibodies  >1 publications with CLPX and Lymph Node
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