Lassa Virus Nucleoprotein (N) Recombinant Protein

Name: N Recombinant Protein; Lassa Virus Nucleoprotein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS1122803
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1122803

$415 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Lassa virus Nucleoprotein, Recombinant Protein

Full Product Name

Recombinant Lassa virus Nucleoprotein

Product Gene Name

N recombinant protein

Product Synonym Names

Nucleocapsid protein; Protein N

Sequence

MSASKEIKSF LWTQSLRREL SGYCSNIKLQ VVKDAQALLH GLDFSEVSNV QRLMRKERRD DNDLKRLRDL NQAVNNLVEL KSTQQKSILR VGTLTSDDLL ILAADLEKLK SKVIRTERPL SAGVYMGNLS SQQLDQRRAL LNMIGMSGGN QGARAGRDGV VRVWDVKNAE LLNNQFGTMP SLTLACLTKQ GQVDLNDAVQ ALTDLGLIYT AKYPNTSDLD RLTQSHPILN MIDTKKSSLN ISGYNFSLGA AVKAGACMLD GGNMLETIKV SPQTMDGILK SILKVKKALG MFISDTPGER NPYENILYKI CLSGDGWPYI ASRTSITGRA WENTVVDLES DGKPQKADSN NSSKSLQSAG FTAGLTYSQL MTLKDAMLQL DPNAKTWMDI EGRPEDPVEI ALYQPSSGCY IHFFREPTDL KQFKQDAKYS HGIDVTDLFA TQPGLTSAVI DALPRNMVIT CQGSDDIRKL LESQGRKDIK LIDIALSKTD SRKYENAVWD QYKDLCHMHT GVVVEKKKRG GKEEITPHCA LMDCIMFDAA VSGGLNTSVL RAVLPRDMVF RTSTPRVVL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

65 kDa

Sequence Positions

1-569aa? Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P13699

Species

strain Mouse/Sierra Leone/Josiah/1976)(LASV)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for N recombinant protein

Microbiology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for N recombinant protein

"Nucleotide sequence of the Lassa virus (Josiah strain) S genome RNA and amino acid sequence comparison of the N and GPC proteins to other arenaviruses." Auperin D.D., McCormick J.B. Virology 168:421-425(1989)

Other Notes

Small volumes of N recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for N purchase

MBS1122803 is a recombinant protein targeting N. Also known as Recombinant Lassa virus Nucleoprotein. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for N. It may not necessarily be applicable to this product.

NCBI GI #

23343510

NCBI GeneID

956584

NCBI Accession #

NP_694869.1

UniProt Primary Accession #

P13699

GenBank Nucleotide #

NC_004296.1

NCBI Official Full Name

nucleoprotein

NCBI Official Symbol

LASVsSgp1

UniProt Protein Name

Nucleoprotein

UniProt Synonym Protein Names

Nucleocapsid protein; Protein N

UniProt Gene Name

UniProt Entry Name

NCAP_LASSJ

NCBI Protein Information

nucleoprotein

UniProt Comments for N

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation ().

Research Articles on N

1. These results highlight the key role of nucleoprotein exonuclease domain function in the immune evasion that occurs during Lassa virus infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.