Apoptosis Regulatory Protein Siva (SIVA1) Human Recombinant Protein

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.Prasad K.V.S., Ao Z., Yoon Y., Wu M.X., Rizk M., Jacquot S., Schlossman S.F.Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) Characterization of TPA-responsive genes in U937 cells using ordered differential display PCR.Kang H.S., Park Y.J., Jung H.M., Jun D.Y., Huh T.L., Kim Y.H. Apoptosis in coxsackievirus B3-caused diseases interaction between the capsid protein VP2 and the proapoptotic protein siva.Henke A., Launhardt H., Klement K., Stelzner A., Zell R., Munder T.J. Virol. 74:4284-4290(2000) The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress.Cao C., Ren X., Kharbanda S., Koleske A., Prasad K.V.S., Kufe D.J. Biol. Chem. 276:11465-11468(2001) The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva.Henke A., Nestler M., Strunze S., Saluz H.-P., Hortschansky P., Menzel B., Martin U., Zell R., Stelzner A., Munder T.Virology 289:15-22(2001) Siva-1 binds to and inhibits BCL-X(L) -mediated protection against UV radiation-induced apoptosis.Xue L., Chu F., Cheng Y., Sun X., Borthakur A., Ramarao M., Pandey P., Wu M., Schlossman S.F., Prasad K.V.S.Proc. Natl. Acad. Sci. U.S.A. 99:6925-6930(2002) The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis.Chu F., Borthakur A., Sun X., Barkinge J., Gudi R., Hawkins S., Prasad K.V.S.Apoptosis 9:83-95(2004) Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway.Py B., Slomianny C., Auberger P., Petit P.X., Benichou S.J. Immunol. 172:4008-4017(2004) Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells effect of elevated levels of BCL-2.Chu F., Barkinge J., Hawkins S., Gudi R., Salgia R., Kanteti P.V.S.Cancer Res. 65:5301-5309(2005) The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.Nestler M., Martin U., Hortschansky P., Saluz H.-P., Henke A., Munder T.Mol. Cell. Biochem. 287:147-155(2006) Siva-1 negatively regulates NF-kappaB activity effect on T-cell receptor-mediated activation-induced cell death (AICD) .Gudi R., Barkinge J., Hawkins S., Chu F., Manicassamy S., Sun Z., Duke-Cohan J.S., Prasad K.V.S.Oncogene 25:3458-3462(2006) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)

Small volumes of SIVA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1132006 is a recombinant protein targeting SIVA1. Also known as Recombinant Human Apoptosis regulatory protein Siva. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.