Growth Hormone Receptor (GHR) Rat Recombinant Protein

GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: extracellular space; extrinsic to membrane; cell surface; mitochondrion; cell soma; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; receptor complex

Molecular Function: growth hormone receptor activity; protein homodimerization activity; peptide hormone binding; growth factor binding; SH2 domain binding; protein phosphatase binding; protein kinase binding

Biological Process: activation of JAK protein; response to peptide hormone stimulus; succinate metabolic process; oxaloacetate metabolic process; hormone-mediated signaling; activation of MAPK activity; response to glucocorticoid stimulus; response to hormone stimulus; positive regulation of JAK-STAT cascade; response to morphine; positive regulation of multicellular organism growth; tyrosine phosphorylation of JAK2 protein; fatty acid metabolic process; response to estradiol stimulus; 2-oxoglutarate metabolic process; allantoin metabolic process; receptor internalization; creatinine metabolic process; response to food; isoleucine metabolic process; cytokine and chemokine mediated signaling pathway; citrate metabolic process; regulation of multicellular organism growth; valine metabolic process; JAK-STAT cascade; creatine metabolic process; multicellular organismal metabolic process; cellular response to hormone stimulus; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; cellular response to insulin stimulus; response to cytokine stimulus; response to cycloheximide; positive regulation of cell differentiation; taurine metabolic process