Human ERAL1 Recombinant Protein – Cat# MBS1159226

Gtpase Era, Mitochondrial (ERAL1) Human Recombinant Protein

Name: ERAL1 Recombinant Protein; Gtpase Era, Mitochondrial; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1159226
Price: 1130 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1159226

MBS1159226 is a recombinant protein targeting ERAL1. Also known as Recombinant Human GTPase Era, mitochondrial (ERAL1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1130 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GTPase Era, mitochondrial (ERAL1), Recombinant Protein

Full Product Name

Recombinant Human GTPase Era, mitochondrial (ERAL1)

Product Gene Name

ERAL1 recombinant protein

Sequence

VSCVAGSAFS GPRLASASRS NGQGSALDHF LGFSQPDSSV TPCVPAVSMN RDEQDVLLVH HPDMPENSRV LRVVLLGAPN AGKSTLSNQL LGRKVFPVSR KVHTTRCQAL GVITEKETQV ILLDTPGIIS PGKQKRHHLE LSLLEDPWKS MESADLVVVL VDVSDKWTRN QLSPQLLRCL TKYSQIPSVL VMNKVDCLKQ KSVLLELTAA LTEGVVNGKK LKMRQAFHSH PGTHCPSPAV KDPNTQSVGN PQRIGWPHFK EIFMLSALSQ EDVKTLKQYL LTQAQPGPWE YHSAVLTSQT PEEICANIIR EKLLEHLPQE VPYNVQQKTA VWEEGPGGEL VIQQKLLVPK ESYVKLLIGP KGHVISQIAQ EAGHDLMDIF LCDVDIRLSV KLLK

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

30,040 Da

Sequence Positions

44-437, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

607435

3D Structure

ModBase 3D Structure for O75616

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ERAL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ERAL1. It may not necessarily be applicable to this product.

NCBI GI #

966209847

NCBI GeneID

26284

NCBI Accession #

NP_001304914.1

UniProt Primary Accession #

O75616

UniProt Secondary Accession #

O75617; Q8WUY4; Q96LE2; Q96TC0; B3KN21; C9JEC6

UniProt Related Accession #

O75616

GenBank Nucleotide #

NM_001317985.1

NCBI Official Full Name

GTPase Era, mitochondrial isoform 2

NCBI Official Synonym Full Names

Era like 12S mitochondrial rRNA chaperone 1

NCBI Official Symbol

ERAL1

NCBI Official Synonym Symbols

ERA; CEGA; ERA-W; H-ERA; ERAL1A; ERAL1B; HERA-A; HERA-B; PRLTS6

UniProt Protein Name

GTPase Era, mitochondrial

UniProt Synonym Protein Names

Conserved ERA-like GTPase; CEGA; ERA-W; ERA-like protein 1

UniProt Gene Name

ERAL1

UniProt Synonym Gene Names

HERA; H-ERA; hERA; CEGA

NCBI Protein Information

GTPase Era, mitochondrial

NCBI Summary for ERAL1

The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

UniProt Comments for ERAL1

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

Research Articles on ERAL1

1. Three women from three different families presented with signs of PS, including deafness and ovarian dysgenesis. We employed exome sequencing and identified a homozygous missense mutation in the ERAL1 gene, c.707A > T. The mutation leads to a damaging p.Asn236Ile substitution that is likely to interfere with the GTP binding capacity of the ERAL1 protein.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ERAL1 recombinant protein

Products by Pathway	Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram
Mitochondrial Translation Pathway antibodies	Mitochondrial Translation Pathway Diagram
Mitochondrial Translation Elongation Pathway antibodies	Mitochondrial Translation Elongation Pathway Diagram
Mitochondrial Translation Initiation Pathway antibodies	Mitochondrial Translation Initiation Pathway Diagram
Mitochondrial Translation Termination Pathway antibodies	Mitochondrial Translation Termination Pathway Diagram
Organelle Biogenesis And Maintenance Pathway antibodies	Organelle Biogenesis And Maintenance Pathway Diagram

Organs/Tissues associated with ERAL1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>2 publications with ERAL1 and Prostate