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PRMT1 Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203117

Protein arginine N-methyltransferase 1 (PRMT1) is a type I methyltransferase that transfers a methyl group from S-adenosylmethionine to guanidino nitrogens of arginine residues to form monomethylarginine and asymmetric dimethylarginine. Functions of type I… More details

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Product Overview

Online Datasheet in PDF
Product Name
PRMT1, Active Protein
Full Product Name
Mouse PRMT1 isoform2, 1-353aa, mouse, His-MBP tag, E Coli (Bioactivity Validated)
Product Gene Name
PRMT1 active protein
Product Synonym Names
Protein arginine N-methyltransferase 1; Mrmt1; Hrmt112; AW214366; Protein arginine N-methytransferase 1; PRMT1 isoform2; PRMT1; Protein arginine N-methyltransferase 1 ANM 1; HCP 1; HMT1 hnRNP methyltransferase; Heterogeneous nuclear ribonucleoproteins methyltransferase like 2; HMT2; HRMT1 L2; HRMT1L 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like2; HMT 2; HMT1 (hnRNP methyltransferase S; cerevisiae) like 2; HMT1 hnRNP methyltransferase like 2; HMT1 hnRNP methyltransferase like 2 (S; cerevisiae); Human mRNA for suppressor for yeast mutant; Human mRNA for suppressor for yeast mutant complete cds; Interferon receptor 1 bound protein 4; Interferon receptor 1 bound protein4; Interferon receptor 1bound protein 4; IR1 B4; IR1B 4; Mrmt 1; Mrmt1; PRMT 1; R1B4; S; cerevisiae like 2; Protein arginine N methyltransferase 1; Protein arginine N methyltransferase1
Sequence
MHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFW AHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEI PALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNK HMNADTDYSI AEAAFNKGET AMTINGPWAW SNIDTSKVNY GVTVLPTFKG QPSKPFVGVL SAGINAASPN KELAKEFLEN YLLTDEGLEA VNKDKPLGAV ALKSYEEELA KDPRIAATME NAQKGEIMPN IPQMSAFWYA VRTAVINAAS GRQTVDEALK DAQTNSSSNN NNNNNNNNLG IEGRGSHMAA AEAANCIMEV SCGQAESSEK PNAEDMTSKD YYFDSYAHFG IHEEMLKDEV RTLTYRNSMF HNRHLFKDKV VLDVGSGTGI LCMFAAKAGA RKVIGIECSS ISDYAVKIVK ANKLDHVVTI IKGKVEEVEL PVEKVDIIIS EWMGYCLFYE SMLNTVLHAR DKWLAPDGLI FPDRATLYVT AIEDRQYKDY KIHWWENVYG FDMSCIKDVA IKEPLVDVVD PKQLVTNACL IKEVDIYTVK VEDLTFTSPF CLQVKRNDYV HALVAYFNIE FTRCHKRTGF STSPESPYTH WKQTVFYMED YLTVKTGEEI FGTIGMRPNA KNNRDLDFTI DLDFKGQLCE LSCSTDYRMR
Host
E Coli
Form/Format
Liquid in 40mM Tris pH 8.0, 100mM NaCl, 4mM MgCl2, 2mM DTT, 40% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
84 kDa (750 aa)
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Antigen Species
Mouse
Tag Information
His-MBP tag
Biological Activity
Specific activity is > 30 nmol/min/mg, and is defined as the amount of enzyme that transfer 1.0 nmole of methyl group per minute at 37C.

Product Categories/Family for PRMT1 active protein

Histone Related
Applications Tested/Suitable for PRMT1 active protein
SDS-PAGE

SDS-Page of PRMT1 active protein

Mouse PRMT1 Active Protein – Cat# MBS203117

Product References and Citations for PRMT1 active protein

Herrmann F., et al. (2005). J Biol Chem. 280 (45):38005-10.; Abramovich C., et al. (1997). EMBO J. 16 (2):260-6. ;

Other Notes

Small volumes of PRMT1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRMT1 purchase

MBS203117 is an active protein targeting PRMT1. Also known as Mouse PRMT1 isoform2, 1-353aa, mouse, His-MBP tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRMT1. It may not necessarily be applicable to this product.

NCBI GI #
7141328
NCBI GeneID
15469
NCBI Accession #
AAF37293
UniProt Secondary Accession #
Q99LS4
UniProt Related Accession #
Q9JIF0
NCBI Official Full Name
protein arginine N-methyltransferase 1
NCBI Official Synonym Full Names
protein arginine N-methyltransferase 1
NCBI Official Symbol
Prmt1
NCBI Official Synonym Symbols
Mrmt1; Hrmt1l2; AW214366; 6720434D09Rik
UniProt Protein Name
Protein arginine N-methyltransferase 1
UniProt Synonym Protein Names
Histone-arginine N-methyltransferase PRMT1
Protein Family
Probable protein arginine N-methyltransferase
UniProt Gene Name
Prmt1
UniProt Synonym Gene Names
Hrmt1l2; Mrmt1
NCBI Protein Information
protein arginine N-methyltransferase 1

UniProt Comments for PRMT1

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity. Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (). Promotes colorectal cancer cell malignancy ().
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Research Articles on PRMT1

1. PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRMT1 active protein

 Reference Product  PubMed Publications
 Prmt5 active protein  >54 publications with PRMT1 and Prmt5
 Foxo1 active protein  >7 publications with PRMT1 and Foxo1
 Khdrbs1 active protein  >6 publications with PRMT1 and Khdrbs1

Pathways associated with PRMT1 active protein

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with PRMT1 active protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >31 publications with PRMT1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >28 publications with PRMT1 and Disease Models, Animal
 Heart Diseases Antibodies  >18 publications with PRMT1 and Heart Diseases
 Inflammation Antibodies  >16 publications with PRMT1 and Inflammation
 Lung Diseases Antibodies  >16 publications with PRMT1 and Lung Diseases
 Liver Diseases Antibodies  >13 publications with PRMT1 and Liver Diseases
 Hepatitis Antibodies  >12 publications with PRMT1 and Hepatitis
 Necrosis Antibodies  >10 publications with PRMT1 and Necrosis
 Kidney Diseases Antibodies  >9 publications with PRMT1 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >9 publications with PRMT1 and Cell Transformation, Neoplastic

Organs/Tissues associated with PRMT1 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >58 publications with PRMT1 and Blood
 Liver Antibodies  >37 publications with PRMT1 and Liver
 Brain Antibodies  >36 publications with PRMT1 and Brain
 Muscle Antibodies  >28 publications with PRMT1 and Muscle
 Heart Antibodies  >26 publications with PRMT1 and Heart
 Lung Antibodies  >24 publications with PRMT1 and Lung
 Kidney Antibodies  >21 publications with PRMT1 and Kidney
 Bone Antibodies  >13 publications with PRMT1 and Bone
 Intestine Antibodies  >11 publications with PRMT1 and Intestine
 Embryonic Tissue Antibodies  >9 publications with PRMT1 and Embryonic Tissue
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