Mouse BLM Recombinant Protein – Cat# MBS1163057

Bloom Syndrome Protein Homolog (Blm), Partial (BLM) Mouse Recombinant Protein

Name: BLM Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1163057
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1163057

MBS1163057 is a recombinant protein targeting Blm. Also known as Recombinant Mouse Bloom syndrome protein homolog (Blm), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Blm More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Bloom syndrome protein homolog (Blm), partial, Recombinant Protein

Full Product Name

Recombinant Mouse Bloom syndrome protein homolog (Blm), partial

Product Gene Name

Blm recombinant protein

Product Synonym Names

Bloom syndrome protein homolog; mBLM; EC=3.6.4.12; RecQ helicase homolog

Sequence

INAALLGEDC FILMPTGGGK SLCYQLPACV SPGVTIVISP LRSLIVDQVQ KLTSFDIPAT YLTGDKTDSE AANIYLQLSK KDPIIKLLYV TPEKVCASNR LISTLENLYE RKLLARFVID EAHCVSQWGH DFRQDYKRMN MLRQKFPSVP VMALTATANP RVQKDILTQL KILRPQ

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

24.7 kDa

Sequence Positions

684-859aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O88700

Species

Mus musculus (Mouse)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for Blm recombinant protein

Neuroscience

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Blm recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Blm. It may not necessarily be applicable to this product.

NCBI GI #

110225360

NCBI GeneID

12144

NCBI Accession #

NP_001035992.1

UniProt Primary Accession #

O88700

UniProt Secondary Accession #

O88198

UniProt Related Accession #

O88700

GenBank Nucleotide #

NM_001042527.2

NCBI Official Full Name

Bloom syndrome protein homolog isoform 2

NCBI Official Synonym Full Names

Bloom syndrome, RecQ helicase-like

NCBI Official Symbol

Blm

UniProt Protein Name

Bloom syndrome protein homolog

UniProt Synonym Protein Names

RecQ helicase homolog

Protein Family

Bloom syndrome protein

UniProt Gene Name

Blm

UniProt Synonym Gene Names

mBLM

UniProt Entry Name

BLM_MOUSE

NCBI Protein Information

Bloom syndrome protein homolog; mBLM; recQ helicase homolog; Bloom syndrome homolog

UniProt Comments for Blm

BLM: a magnesium-dependent ATP-dependent DNA-helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. A member of the RecQ helicase family that is required for genome stability. Participates in DNA replication, recombination and repair. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex which is a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ubiquitinated FANCD2.

Protein type: EC 3.6.4.12; Helicase; DNA replication; DNA repair, damage

Cellular Component: male germ cell nucleus; nuclear chromosome; lateral element; chromosome, telomeric region; PML body; nuclear matrix; pronucleus; cytoplasm; nucleolus; replication fork; intracellular; nucleus

Molecular Function: G-quadruplex DNA binding; hydrolase activity; p53 binding; ATPase activity; nucleotide binding; ATP-dependent helicase activity; bubble DNA binding; helicase activity; ATP-dependent DNA helicase activity; four-way junction helicase activity; protein binding; nucleic acid binding; DNA binding; ATP-dependent 3'-5' DNA helicase activity; catalytic activity; single-stranded DNA binding; ATP binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Biological Process: negative regulation of DNA recombination; regulation of binding; positive regulation of transcription, DNA-dependent; DNA double-strand break processing; negative regulation of mitotic recombination; alpha-beta T cell differentiation; negative regulation of cell division; DNA repair; chromosome organization and biogenesis; protein oligomerization; DNA duplex unwinding; DNA recombination; replication fork processing; cellular metabolic process; mitotic cell cycle G2/M transition DNA damage checkpoint; DNA strand renaturation; positive regulation of alpha-beta T cell proliferation; regulation of cyclin-dependent protein kinase activity; DNA replication; response to DNA damage stimulus; telomere maintenance; response to X-ray

Research Articles on Blm

1. Data suggest that BLM suppresses homologous recombination, while full-length BRCA1 promotes this process.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Blm recombinant protein

Reference Product	PubMed Publications
Rad51 recombinant protein	>67 publications with Blm and Rad51

Pathways associated with Blm recombinant protein

Products by Pathway	Pathway Diagram
BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies	BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
Bloom's Syndrome Complex Pathway antibodies	Bloom's Syndrome Complex Pathway Diagram
Fanconi Anemia Pathway antibodies	Fanconi Anemia Pathway Diagram
Fanconi Anemia Pathway antibodies	Fanconi Anemia Pathway Diagram
Homologous Recombination Pathway antibodies	Homologous Recombination Pathway Diagram
Homologous Recombination Pathway antibodies	Homologous Recombination Pathway Diagram

Diseases associated with Blm recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>581 publications with Blm and Neoplasms
Bloom Syndrome Antibodies	>393 publications with Blm and Bloom Syndrome
Drug Toxicity Antibodies	>363 publications with Blm and Drug Toxicity
Disease Models, Animal Antibodies	>170 publications with Blm and Disease Models, Animal
Neoplasms, Experimental Antibodies	>139 publications with Blm and Neoplasms, Experimental
Head and Neck Neoplasms Antibodies	>131 publications with Blm and Head and Neck Neoplasms
Chromosome Aberrations Antibodies	>123 publications with Blm and Chromosome Aberrations
Carcinoma, Squamous Cell Antibodies	>114 publications with Blm and Carcinoma, Squamous Cell
Inflammation Antibodies	>90 publications with Blm and Inflammation
Skin Diseases Antibodies	>78 publications with Blm and Skin Diseases

Organs/Tissues associated with Blm recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>376 publications with Blm and Lung
Intestine Antibodies	>91 publications with Blm and Intestine
Bone Antibodies	>58 publications with Blm and Bone
Brain Antibodies	>52 publications with Blm and Brain
Spleen Antibodies	>36 publications with Blm and Spleen
Bone Marrow Antibodies	>33 publications with Blm and Bone Marrow
Ovary Antibodies	>33 publications with Blm and Ovary
Thymus Antibodies	>25 publications with Blm and Thymus
Heart Antibodies	>25 publications with Blm and Heart
Stomach Antibodies	>19 publications with Blm and Stomach