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Solute Carrier Family 22 Member 2 (SLC22A2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1165458

MBS1165458 is a recombinant protein targeting SLC22A2. Also known as Recombinant Human Solute carrier family 22 member 2 (SLC22A2), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1895 / 1 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Solute carrier family 22 member 2 (SLC22A2), Recombinant Protein
Full Product Name
Recombinant Human Solute carrier family 22 member 2 (SLC22A2), partial
Product Gene Name
SLC22A2 recombinant protein
Sequence
MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR CRSPGVAELS LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST FDCVDPLASL DTNRSRLPLG PCRDGWVYET PGSSIVTEFN LVCANSWMLD LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL LTTVLINAAA GVLMAISPTY TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF YQVAYTVGLL VLAGVAYALP HWRWLQFTVS LPNFFFLLYY WCIPESPRWL ISQNKNAEAM RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI LMYNWFTSSV LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR IGRRYPWAAS NMVAGAACLA SVFIPGDLQW LKIIISCLGR MGITMAYEIV CLVNAELYPT FIRNLGVHIC SSMCDIGGII TPFLVYRLTN IWLELPLMVF GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE KMIYLQVQKL DIPLN
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
26,685 Da
Sequence Positions
1-555
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
602608
3D Structure
ModBase 3D Structure for O15244
Species
Homo sapiens (Human)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SLC22A2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC22A2. It may not necessarily be applicable to this product.

NCBI GI #
302148518
NCBI GeneID
6582
NCBI Accession #
NP_003049.2
UniProt Primary Accession #
O15244
UniProt Secondary Accession #
Q5T7Q6; Q6PIQ8; Q8NG62; Q9NQB9
UniProt Related Accession #
O15244
GenBank Nucleotide #
NM_003058.3
NCBI Official Full Name
solute carrier family 22 member 2
NCBI Official Synonym Full Names
solute carrier family 22 member 2
NCBI Official Symbol
SLC22A2
NCBI Official Synonym Symbols
OCT2
UniProt Protein Name
Solute carrier family 22 member 2
UniProt Synonym Protein Names
Organic cation transporter 2; hOCT2
Protein Family
Solute carrier family
UniProt Gene Name
SLC22A2
UniProt Synonym Gene Names
OCT2; hOCT2
NCBI Protein Information
solute carrier family 22 member 2

NCBI Summary for SLC22A2

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
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UniProt Comments for SLC22A2

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
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Research Articles on SLC22A2

1. SLC22A2 deletion is associated with motor speech disorders, and language delays.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SLC22A2 recombinant protein

 Reference Product  PubMed Publications
 POU2AF1 recombinant protein  >11 publications with SLC22A2 and POU2AF1

Pathways associated with SLC22A2 recombinant protein

 Products by Pathway  Pathway Diagram
 Abacavir Transmembrane Transport Pathway antibodies  Abacavir Transmembrane Transport Pathway Diagram
 Abacavir Transport And Metabolism Pathway antibodies  Abacavir Transport And Metabolism Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Na+/Cl- Dependent Neurotransmitter Transporters Pathway antibodies  Na+/Cl- Dependent Neurotransmitter Transporters Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Clearance In The Synaptic Cleft Pathway antibodies  Neurotransmitter Clearance In The Synaptic Cleft Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Norepinephrine Neurotransmitter Release Cycle Pathway antibodies  Norepinephrine Neurotransmitter Release Cycle Pathway Diagram

Diseases associated with SLC22A2 recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >33 publications with SLC22A2 and Kidney Diseases
 Acute Kidney Injury Antibodies  >13 publications with SLC22A2 and Acute Kidney Injury
 Hypertension Antibodies  >10 publications with SLC22A2 and Hypertension
 Necrosis Antibodies  >5 publications with SLC22A2 and Necrosis
 Poisoning Antibodies  >4 publications with SLC22A2 and Poisoning
 Basal Ganglia Diseases Antibodies  >3 publications with SLC22A2 and Basal Ganglia Diseases
 Movement Disorders Antibodies  >3 publications with SLC22A2 and Movement Disorders
 Heart Diseases Antibodies  >3 publications with SLC22A2 and Heart Diseases
 Mental Disorders Antibodies  >2 publications with SLC22A2 and Mental Disorders
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with SLC22A2 and Drug-Related Side Effects and Adverse Reactions

Organs/Tissues associated with SLC22A2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >196 publications with SLC22A2 and Kidney
 Brain Antibodies  >27 publications with SLC22A2 and Brain
 Placenta Antibodies  >14 publications with SLC22A2 and Placenta
 Connective Tissue Antibodies  >1 publications with SLC22A2 and Connective Tissue
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