Rat PTHLH Recombinant Protein – Cat# MBS1176893

Parathyroid Hormone-Related Protein (PTHLH) Rat Recombinant Protein

Name: PTHLH Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS1176893
Price: 760 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1176893

This protein is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by… More details

$760 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Parathyroid hormone-related protein (Pthlh), Recombinant Protein

Full Product Name

Recombinant Rat Parathyroid hormone-related protein (Pthlh)

Product Gene Name

Pthlh recombinant protein

Sequence

AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAEIRATS EVSPNSKPAP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTPGKKK KGKPGKRREQ EKKKRRTRSA WPGTTGSGLL EDPQPHTSPT STSLEPSSRT H

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

20,204 Da

Sequence Positions

37-177aa; Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P13085

Species

Rat

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Pthlh recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pthlh purchase

MBS1176893 is a recombinant protein targeting Pthlh. Also known as Recombinant Rat Parathyroid hormone-related protein (Pthlh). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Pthlh. It may not necessarily be applicable to this product.

NCBI GI #

6981438

NCBI GeneID

24695

NCBI Accession #

NP_036768.1

UniProt Primary Accession #

P13085

UniProt Related Accession #

P13085

GenBank Nucleotide #

NM_012636.1

NCBI Official Full Name

parathyroid hormone-related protein preproprotein

NCBI Official Synonym Full Names

parathyroid hormone-like hormone

NCBI Official Symbol

Pthlh

NCBI Official Synonym Symbols

PLP

UniProt Protein Name

Parathyroid hormone-related protein

UniProt Synonym Protein Names

Parathyroid hormone-like protein; PLP

Protein Family

Parathyroid hormone-related protein

UniProt Gene Name

Pthlh

UniProt Synonym Gene Names

Pthrp; PTH-rP; PTHrP; PLP

NCBI Protein Information

parathyroid hormone-related protein

NCBI Summary for Pthlh

induces vasodilation; may play a neuroprotective role in response to ischemic brain injury [RGD, Feb 2006]

UniProt Comments for Pthlh

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath ().

Research Articles on Pthlh

1. These results indicate that the well-conserved region in the signal peptide plays an essential role in the dual localization of PTHrP through ER targeting and/or the membrane translocation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Pthlh recombinant protein

Reference Product	PubMed Publications
Pth recombinant protein	>444 publications with Pthlh and Pth
Ihh recombinant protein	>20 publications with Pthlh and Ihh
Pthr1 recombinant protein	>7 publications with Pthlh and Pthr1
Shh recombinant protein	>4 publications with Pthlh and Shh
Il6 recombinant protein	>3 publications with Pthlh and Il6
Pth2r recombinant protein	>3 publications with Pthlh and Pth2r
Vegfa recombinant protein	>2 publications with Pthlh and Vegfa
Igf1 recombinant protein	>1 publications with Pthlh and Igf1

Pathways associated with Pthlh recombinant protein

Products by Pathway	Pathway Diagram
Class B/2 (Secretin Family Receptors) Pathway antibodies	Class B/2 (Secretin Family Receptors) Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with Pthlh recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>741 publications with Pthlh and Neoplasms
Hypercalcemia Antibodies	>611 publications with Pthlh and Hypercalcemia
Bone Resorption Antibodies	>139 publications with Pthlh and Bone Resorption
Breast Neoplasms Antibodies	>122 publications with Pthlh and Breast Neoplasms
Carcinoma, Squamous Cell Antibodies	>113 publications with Pthlh and Carcinoma, Squamous Cell
Lung Neoplasms Antibodies	>102 publications with Pthlh and Lung Neoplasms
Lung Diseases Antibodies	>88 publications with Pthlh and Lung Diseases
Kidney Diseases Antibodies	>67 publications with Pthlh and Kidney Diseases
Necrosis Antibodies	>48 publications with Pthlh and Necrosis
Liver Neoplasms Antibodies	>47 publications with Pthlh and Liver Neoplasms

Organs/Tissues associated with Pthlh recombinant protein

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>43 publications with Pthlh and Prostate
Brain Antibodies	>28 publications with Pthlh and Brain
Ovary Antibodies	>15 publications with Pthlh and Ovary