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CASP8 and FADD-Like Apoptosis Regulator (CFLAR) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1189189

MBS1189189 is a recombinant protein targeting Cflar. Also known as Recombinant Mouse CASP8 and FADD-like apoptosis regulator (Cflar). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1115 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CASP8 and FADD-like apoptosis regulator (Cflar), Recombinant Protein
Full Product Name
Recombinant Mouse CASP8 and FADD-like apoptosis regulator (Cflar)
Product Gene Name
Cflar recombinant protein
Sequence
MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS ERGQLSFATL AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV LLMEIGESLD QNDVSSLVFL TRDYTGRGKI AKDKSFLDLV IELEKLNLIA SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS QGARSNMNTL QASLPKLSIK PSVLYLKLQN GRSKEPRFVE YRDSQRTLVK TSIQESGAFL PPHIREETYR MQSKPLGICL IIDCIGNDTK YLQETFTSLG YHIQLFLFPK SHDITQIVRR YASMAQHQDY DSFACVLVSL GGSQSMMGRD QVHSGFSLDH VKNMFTGDTC PSLRGKPKLF FIQNYESLGS QLEDSSLEVD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
24,534 Da
Sequence Positions
1-380, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for O35732
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cflar recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cflar. It may not necessarily be applicable to this product.

NCBI GI #
576067795
NCBI GeneID
12633
NCBI Accession #
NP_001276633.1
UniProt Primary Accession #
O35732
UniProt Secondary Accession #
O35707; O35733; D3Z0W6
UniProt Related Accession #
O35732
GenBank Nucleotide #
NM_001289704.3
NCBI Official Full Name
CASP8 and FADD-like apoptosis regulator isoform 1
NCBI Official Synonym Full Names
CASP8 and FADD-like apoptosis regulator
NCBI Official Symbol
Cflar
NCBI Official Synonym Symbols
Cash; Flip; MRIT; CLARP; FLAME; Casper; Gm9845; c-Flip; FLAME-1; I-FLICE; 2310024N18Rik; A430105C05Rik
UniProt Protein Name
CASP8 and FADD-like apoptosis regulator
UniProt Synonym Protein Names
Caspase homolog; CASH
Protein Family
CASP8 and FADD-like apoptosis regulator
UniProt Gene Name
Cflar
UniProt Synonym Gene Names
Cash; CASH; Casper; CLARP; c-FLIP; FLAME-1; I-FLICE; MRIT
NCBI Protein Information
CASP8 and FADD-like apoptosis regulator

UniProt Comments for Cflar

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity ().
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Research Articles on Cflar

1. Deletion of c-FLIP from CD11b(hi) Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Cflar recombinant protein

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Dimerization Of Procaspase-8 Pathway antibodies  Dimerization Of Procaspase-8 Pathway Diagram

Diseases associated with Cflar recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >379 publications with Cflar and Necrosis
 Leukemia Antibodies  >74 publications with Cflar and Leukemia
 Adenocarcinoma Antibodies  >56 publications with Cflar and Adenocarcinoma
 Inflammation Antibodies  >47 publications with Cflar and Inflammation
 Lung Neoplasms Antibodies  >32 publications with Cflar and Lung Neoplasms
 Liver Diseases Antibodies  >30 publications with Cflar and Liver Diseases
 Nervous System Diseases Antibodies  >29 publications with Cflar and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >26 publications with Cflar and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >25 publications with Cflar and Breast Neoplasms
 Disease Models, Animal Antibodies  >22 publications with Cflar and Disease Models, Animal

Organs/Tissues associated with Cflar recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >231 publications with Cflar and Blood
 Liver Antibodies  >51 publications with Cflar and Liver
 Lung Antibodies  >45 publications with Cflar and Lung
 Prostate Antibodies  >39 publications with Cflar and Prostate
 Skin Antibodies  >29 publications with Cflar and Skin
 Kidney Antibodies  >28 publications with Cflar and Kidney
 Brain Antibodies  >28 publications with Cflar and Brain
 Bone Marrow Antibodies  >23 publications with Cflar and Bone Marrow
 Embryonic Tissue Antibodies  >15 publications with Cflar and Embryonic Tissue
 Spleen Antibodies  >14 publications with Cflar and Spleen
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