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KIF2C Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120222

The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for… More details

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Product Overview

Online Datasheet in PDF
Product Name
KIF2C, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human KIF2C
Product Gene Name
anti-KIF2C antibody
Product Synonym Names
Homo sapiens kinesin family member 2C (KIF2C); MCAK; KNSL6
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2488C3a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Molecular Weight
75,561 Da
OMIM
604538
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-KIF2C antibody
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)

Quality Control of anti-KIF2C antibody

Western blot analysis of immunized recombinant protein, using anti-KIF2C monoclonal antibody.
Mouse Anti-KIF2C Monoclonal Antibody – Cat# MBS120222

Quality Control #2 of anti-KIF2C antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-KIF2C Monoclonal Antibody, Quality Control #2 – Cat# MBS120222

Western Blot (WB) of anti-KIF2C antibody

Detection of human KIF2C by Western blot.

Samples: Whole cell lysate (25 ug) from HeLa cells. [Lot No. 2488C3a-1]

Predicted molecular weight: 81 kDa
Mouse Anti-KIF2C Monoclonal Antibody, Western Blot (WB) – Cat# MBS120222

Flow Cytometry (FC/FACS) of anti-KIF2C antibody

HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-KIF2C mAb (shaded) or isotype control (unshaded) followed by Alexa Fluor(R) 488-conjugated goat anti-mouse IgG. [Lot No. 2488C3a-1]
Mouse Anti-KIF2C Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS120222

Immunocytochemistry (ICC) of anti-KIF2C antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-KIF2C mAb. Nuclear was stained with Hoechst (blue fluorescence).[Lot No. 2488C3a-1]
Mouse Anti-KIF2C Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS120222

Other Notes

Small volumes of anti-KIF2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIF2C purchase

MBS120222 is an antibody targeting KIF2C. Also known as Mouse monoclonal antibody Anti-Human KIF2C. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KIF2C. It may not necessarily be applicable to this product.

NCBI GI #
166795249
NCBI GeneID
11004
NCBI Accession #
NP_006836.2
UniProt Secondary Accession #
Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q9BWV8; B3ITR9
UniProt Related Accession #
Q99661
GenBank Nucleotide #
NM_006845
NCBI Official Full Name
Homo sapiens kinesin family member 2C (KIF2C), transcript variant 1, mRNA
NCBI Official Synonym Full Names
kinesin family member 2C
NCBI Official Symbol
KIF2C
NCBI Official Synonym Symbols
MCAK; CT139; KNSL6
UniProt Protein Name
Kinesin-like protein KIF2C
UniProt Synonym Protein Names
Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK
Protein Family
Kinesin-like protein
UniProt Gene Name
KIF2C
UniProt Entry Name
KIF2C_HUMAN
NCBI Protein Information
kinesin-like protein KIF2C; kinesin-like protein 6; mitotic centromere-associated kinesin

NCBI Summary for KIF2C

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for KIF2C

KIF2C: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cancer Testis Antigen (CTA); Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: kinetochore; microtubule cytoskeleton; kinesin complex; membrane; cytoplasmic microtubule; nucleus; cytosol; chromosome, pericentric region

Molecular Function: centromeric DNA binding; microtubule plus-end binding; protein binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: cell proliferation; mitosis; cell division; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule depolymerization; regulation of chromosome segregation; mitotic cell cycle; blood coagulation; mitotic metaphase plate congression; microtubule-based movement; establishment and/or maintenance of microtubule cytoskeleton polarity
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Research Articles on KIF2C

1. this study suggests a new mechanism by which Plk1 regulates MCAK: by regulating its degradation and hence controlling its turnover in mitosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KIF2C antibody

 Reference Product  PubMed Publications
 AURKB antibody  >17 publications with KIF2C and AURKB
 BIRC5 antibody  >8 publications with KIF2C and BIRC5
 BUB1 antibody  >6 publications with KIF2C and BUB1
 CDC20 antibody  >3 publications with KIF2C and CDC20
 CDCA8 antibody  >3 publications with KIF2C and CDCA8
 PLK1 antibody  >3 publications with KIF2C and PLK1
 MAPRE1 antibody  >2 publications with KIF2C and MAPRE1
 CENPA antibody  >1 publications with KIF2C and CENPA
 NDC80 antibody  >1 publications with KIF2C and NDC80

Pathways associated with anti-KIF2C antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Kinesins Pathway antibodies  Kinesins Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram

Diseases associated with anti-KIF2C antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >5 publications with KIF2C and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with KIF2C and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >2 publications with KIF2C and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with KIF2C and Nervous System Diseases
 Adenocarcinoma Antibodies  >2 publications with KIF2C and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with KIF2C and Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >1 publications with KIF2C and Prostatic Neoplasms
 Atherosclerosis Antibodies  >1 publications with KIF2C and Atherosclerosis
 Lung Neoplasms Antibodies  >1 publications with KIF2C and Lung Neoplasms
 Liver Neoplasms Antibodies  >1 publications with KIF2C and Liver Neoplasms

Organs/Tissues associated with anti-KIF2C antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with KIF2C and Blood
 Lung Antibodies  >4 publications with KIF2C and Lung
 Testis Antibodies  >4 publications with KIF2C and Testis
 Intestine Antibodies  >2 publications with KIF2C and Intestine
 Lymph Node Antibodies  >2 publications with KIF2C and Lymph Node
 Lymph Antibodies  >2 publications with KIF2C and Lymph
 Brain Antibodies  >2 publications with KIF2C and Brain
 Stomach Antibodies  >1 publications with KIF2C and Stomach
 Muscle Antibodies  >1 publications with KIF2C and Muscle
 Liver Antibodies  >1 publications with KIF2C and Liver
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