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C14ORF169 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120275

May play a role in ribosome biogenesis and in the replication or remodelling of certain heterochromatic region. [UniProtKB Function] More details

$575 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
C14orf169, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human C14orf169
Product Gene Name
anti-C14orf169 antibody
Product Synonym Names
Homo sapiens chromosome 14 open reading frame 169 (C14orf169); FLJ21802
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3354C5a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Molecular Weight
48,687 Da
OMIM
611919
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-C14orf169 antibody
Dot Blot (DB)

Quality Control of anti-C14orf169 antibody

Western blot analysis of immunized recombinant protein, using anti-C14orf169 monoclonal antibody.
Mouse Anti-C14ORF169 Monoclonal Antibody – Cat# MBS120275

Quality Control #2 of anti-C14orf169 antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-C14ORF169 Monoclonal Antibody, Quality Control #2 – Cat# MBS120275

Other Notes

Small volumes of anti-C14orf169 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C14orf169 purchase

MBS120275 is an antibody targeting C14orf169. Also known as Mouse monoclonal antibody Anti-Human C14orf169. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for C14orf169. It may not necessarily be applicable to this product.

NCBI GI #
585866246
NCBI GeneID
79697
NCBI Accession #
NP_078920.2
UniProt Secondary Accession #
B4DT02
UniProt Related Accession #
Q9H6W3
GenBank Nucleotide #
NM_024644
NCBI Official Full Name
Homo sapiens chromosome 14 open reading frame 169 (C14orf169), mRNA
NCBI Official Synonym Full Names
chromosome 14 open reading frame 169
NCBI Official Symbol
C14orf169
NCBI Official Synonym Symbols
ROX; NO66; MAPJD; URLC2; hsNO66
UniProt Protein Name
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
UniProt Synonym Protein Names
60S ribosomal protein L8 histidine hydroxylase; Histone lysine demethylase NO66; Myc-associated protein with JmjC domain; Nucleolar protein 66; hsNO66; Ribosomal oxygenase NO66; ROX
UniProt Gene Name
NO66
UniProt Entry Name
NO66_HUMAN
NCBI Protein Information
bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; 60S ribosomal protein L8 histidine hydroxylase; MYC-associated protein with JmjC domain; histone lysine demethylase NO66; lysine-specific demethylase NO66; nucleolar protein 66; ribosomal oxygenase NO66; up-regulated in lung cancer 2

UniProt Comments for C14orf169

NO66: Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. Belongs to the MINA53/NO66 family. NO66 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.27; Nucleolus

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: histone demethylase activity (H3-K4 specific); protein binding; histone demethylase activity (H3-K36 specific); iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Biological Process: transcription, DNA-dependent; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent
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Research Articles on C14orf169

1. hinge domain-dependent oligomerization of NO66 is essential for inhibition of Osx-dependent gene activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-C14orf169 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with C14orf169 and Inflammation
 Necrosis Antibodies  >1 publications with C14orf169 and Necrosis

Organs/Tissues associated with anti-C14orf169 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3 publications with C14orf169 and Bone
 Brain Antibodies  >1 publications with C14orf169 and Brain
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