• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ORC6L Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120389

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a… More details

$575 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ORC6L, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human ORC6L
Product Gene Name
anti-ORC6L antibody
Product Synonym Names
Homo sapiens origin recognition complex, subunit 6 like (yeast) (ORC6L), mRNA.; ORC6
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2679C2b
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Molecular Weight
28,107 Da
OMIM
607213
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-ORC6L antibody
Dot Blot (DB), Immunocytochemistry (ICC)

Quality Control of anti-ORC6L antibody

Western blot analysis of immunized recombinant protein, using anti-ORC6L monoclonal antibody.
Mouse Anti-ORC6L Monoclonal Antibody – Cat# MBS120389

Quality Control #2 of anti-ORC6L antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-ORC6L Monoclonal Antibody, Quality Control #2 – Cat# MBS120389

Immunocytochemistry (ICC) of anti-ORC6L antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-ORC6L mAb. [Lot No.2679C2b-1]
Mouse Anti-ORC6L Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS120389

Other Notes

Small volumes of anti-ORC6L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ORC6L purchase

MBS120389 is an antibody targeting ORC6L. Also known as Mouse monoclonal antibody Anti-Human ORC6L. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ORC6L. It may not necessarily be applicable to this product.

NCBI GI #
313661351
NCBI GeneID
23594
NCBI Accession #
NP_055136.1
UniProt Secondary Accession #
B3KN89
UniProt Related Accession #
Q9Y5N6
GenBank Nucleotide #
NM_014321
NCBI Official Full Name
Homo sapiens origin recognition complex, subunit 6 (ORC6), transcript variant 1, mRNA
NCBI Official Synonym Full Names
origin recognition complex, subunit 6
NCBI Official Symbol
ORC6
NCBI Official Synonym Symbols
ORC6L
UniProt Protein Name
Origin recognition complex subunit 6
UniProt Gene Name
ORC6
UniProt Entry Name
ORC6_HUMAN
NCBI Protein Information
origin recognition complex subunit 6

NCBI Summary for ORC6L

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Show more

UniProt Comments for ORC6L

ORC6L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: nucleoplasm; membrane; plasma membrane; nucleus; nuclear origin of replication recognition complex; origin recognition complex

Molecular Function: protein binding; DNA binding

Biological Process: mitotic cell cycle; DNA replication; DNA-dependent DNA replication; G1/S transition of mitotic cell cycle

Disease: Meier-gorlin Syndrome 3
Show more

Research Articles on ORC6L

1. findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ORC6L antibody

 Reference Product  PubMed Publications
 CDC6 antibody  >23 publications with ORC6L and CDC6
 CDC45 antibody  >2 publications with ORC6L and CDC45
 MCM5 antibody  >1 publications with ORC6L and MCM5
 MCM4 antibody  >1 publications with ORC6L and MCM4
 CDC7 antibody  >1 publications with ORC6L and CDC7

Pathways associated with anti-ORC6L antibody

 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The ORC Complex At The Origin Of Replication Pathway antibodies  Assembly Of The ORC Complex At The Origin Of Replication Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 CDC6 Association With The ORC:origin Complex Pathway antibodies  CDC6 Association With The ORC:origin Complex Pathway Diagram
 CDT1 Association With The CDC6:ORC:origin Complex Pathway antibodies  CDT1 Association With The CDC6:ORC:origin Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with anti-ORC6L antibody

 Disease Name  Pubmed Publications
 Meier-Gorlin syndrome Antibodies  >7 publications with ORC6L and Meier-Gorlin syndrome
 Nervous System Diseases Antibodies  >1 publications with ORC6L and Nervous System Diseases

Organs/Tissues associated with anti-ORC6L antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >5 publications with ORC6L and Bone
 Ear Antibodies  >4 publications with ORC6L and Ear
 Blood Antibodies  >1 publications with ORC6L and Blood
 Muscle Antibodies  >1 publications with ORC6L and Muscle
 Mouth Antibodies  >1 publications with ORC6L and Mouth
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000