Protein Wnt-8 (wnt8) Xenopus Laevis Recombinant Protein

Ligand for mbers of the frizzled family of seven transmembrane receptors. Plays a role in ventral mesodermal patterning during embryogenesis. Mimics Nieuwkoop center activity. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with noggin and nuclear, sequence-specific DNA-binding protein xBra. None of these molecules causes dorsal mesoderm formation when expressed alone.

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis.Christian J.L., McMahon J.A., McMahon A.P., Moon R.T.Development 111:1045-1055(1991) Xwnt-8b a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis.Cui Y., Brown J.D., Moon R.T., Christian J.L.Development 121:2177-2186(1995) Isolation of cDNAs partially encoding four Xenopus Wnt-1/int-1-related proteins and characterization of their transient expression during embryonic development.Christian J.L., Gavin B.J., McMahon A.P., Moon R.T.Dev. Biol. 143:230-234(1991) Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.Cunliffe V., Smith J.C.EMBO J. 13:349-359(1994) The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.Piccolo S., Agius E., Leyns L., Bhattacharyya S., Grunz H., Bouwmeester T., De Robertis E.M.Nature 397:707-710(1999) Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.Zhang X., Abreu J.G., Yokota C., Macdonald B.T., Singh S., Coburn K.L., Cheong S.M., Zhang M.M., Ye Q.Z., Hang H.C., Steen H., He X.Cell 149:1565-1577(2012) Structural basis of Wnt recognition by Frizzled.Janda C.Y., Waghray D., Levin A.M., Thomas C., Garcia K.C.Science 337:59-64(2012)

Small volumes of wnt8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1208564 is a recombinant protein targeting wnt8. Also known as Recombinant Xenopus laevis Protein Wnt-8. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.