Envelope Glycoprotein E (gE) Equine Herpesvirus 4 Recombinant Protein

Function: In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips

By similarity.

Subunit structure: Interacts with gI

By similarity.

Subcellular location: Virion membrane; Single-pass type I membrane protein

By similarity. Host cell membrane; Single-pass type I membrane protein

By similarity. Host cell junction

By similarity. Host Golgi apparatus membrane; Single-pass membrane protein

By similarity. Host endosome membrane; Single-pass membrane protein

By similarity. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection

By similarity.

Post-translational modification: Phosphorylated on serines within the acidic cluster

Potential. Phosphorylation determines whether endocytosed viral gE traffics to the trans-Golgi network or recycles to the cell membrane

Potential.

Sequence similarities: Belongs to the alphaherpesvirinae glycoprotein E family.