Sterol Regulatory Element-Binding Protein 2 (srebf2) Danio Rerio Recombinant Protein

Function: Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes

By similarity. UniProtKB Q12772

Subunit structure: Forms a tight complex with scap in the ER membrane

By similarity. UniProtKB Q12772

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

By similarity. Golgi apparatus membrane; Multi-pass membrane protein

By similarity. Cytoplasmic vesicle › COPII-coated vesicle membrane; Multi-pass membrane protein

By similarity. Note: Moves from the endoplasmic reticulum to the Golgi in the absence of sterols

By similarity. UniProtKB Q12772Processed sterol regulatory element-binding protein 2: Nucleus

By similarity UniProtKB Q12772.

Post-translational modification: At low cholesterol the scap/srebp complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane

By similarity. UniProtKB Q12772

Sequence similarities: Belongs to the SREBP family.Contains 1 bHLH (basic helix-loop-helix) domain.