Disintegrin and Metalloproteinase Domain-Containing Protein 15 (ADAM15) Mouse Recombinant Protein

ADAM15: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.4.24.-; Protease; Cell adhesion

Cellular Component: cell projection; cell surface; membrane; integral to membrane; cytoplasmic vesicle; intracellular; cell junction

Molecular Function: peptidase activity; integrin binding; protein binding; hydrolase activity; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; metal ion binding; SH3 domain binding

Biological Process: integrin-mediated signaling pathway; collagen catabolic process; innate immune response; angiogenesis; negative regulation of cell growth; negative regulation of cell-matrix adhesion; proteolysis; cell adhesion; negative regulation of cell migration