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Fibroblast Growth Factor 10 (FGF10) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1247804

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fibroblast growth factor 10 (FGF10), Recombinant Protein
Full Product Name
Recombinant Human Fibroblast growth factor 10
Product Gene Name
FGF10 recombinant protein
Product Synonym Names
Keratinocyte growth factor 2
Sequence
QALGQDMVSP EATNSSSSSF SSPSSAGRHV RSYNHLQGDV RWRKLFSFTK YFLKIEKNGK VSGTKKENCP YSILEITSVE IGVVAVKAIN SNYYLAMNKK GKLYGSKEFN NDCKLKERIE ENGYNTYASF NWQHNGRQMY VALNGKGAPR RGQKTRRKNT SAHFLPMVVH S
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
46.3 kDa
Sequence Positions
38-208aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
149730
3D Structure
ModBase 3D Structure for O15520

Product Categories/Family for FGF10 recombinant protein

Cancer
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of FGF10 recombinant protein

Human FGF10 Recombinant Protein – Cat# MBS1247804

Product References and Citations for FGF10 recombinant protein

Structure and expression of human fibroblast growth factor-10.Emoto H., Tagashira S., Mattei M.-G., Yamasaki M., Hashimoto G., Katsumata T., Negoro T., Nakatsuka M., Birnbaum D., Coulier F., Itoh N.J. Biol. Chem. 272:23191-23194(1997) Cutaneous wound healing by keratinocyte growth factor 2.Jimenez P.A., Gruber J.R., Liu B., Feng P., Florence C., Blunt A., Huddleston K.A., Teliska M., Alfonso P., Coleman T.A., Ornitz D.M., Dillon P.A., Duan R.D. Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.Expression of FGF10 in human prostate stromal cells.Nakhla A.M., Hryb D.J., Kahn S.M., Romas N.A., Rosner W. Fibroblast growth factor signalling from development to cancer.Turner N., Grose R.Nat. Rev. Cancer 10:116-129(2010) Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.Yeh B.K., Igarashi M., Eliseenkova A.V., Plotnikov A.N., Sher I., Ron D., Aaronson S.A., Mohammadi M.Proc. Natl. Acad. Sci. U.S.A. 100:2266-2271(2003) Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.Entesarian M., Matsson H., Klar J., Bergendal B., Olson L., Arakaki R., Hayashi Y., Ohuchi H., Falahat B., Bolstad A.I., Jonsson R., Wahren-Herlenius M., Dahl N.Nat. Genet. 37:125-127(2005) LADD syndrome is caused by FGF10 mutations.Milunsky J.M., Zhao G., Maher T.A., Colby R., Everman D.B.Clin. Genet. 69:349-354(2006) Mutations in different components of FGF signaling in LADD syndrome.Rohmann E., Brunner H.G., Kayserili H., Uyguner O., Nuernberg G., Lew E.D., Dobbie A., Eswarakumar V.P., Uzumcu A., Ulubil-Emeroglu M., Leroy J.G., Li Y., Becker C., Lehnerdt K., Cremers C.W.R.J., Yueksel-Apak M., Nuernberg P., Kubisch C., Schlessinger J., van Bokhoven H., Wollnik B.Nat. Genet. 38:414-417(2006)

Other Notes

Small volumes of FGF10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF10 purchase

MBS1247804 is a recombinant protein targeting FGF10. Also known as Recombinant Human Fibroblast growth factor 10. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF10. It may not necessarily be applicable to this product.

NCBI GI #
4758360
NCBI GeneID
2255
NCBI Accession #
NP_004456.1
UniProt Primary Accession #
O15520
UniProt Secondary Accession #
Q6FHR3; Q6FHT6; Q96P59; C7FDY0
UniProt Related Accession #
O15520
GenBank Nucleotide #
NM_004465.1
NCBI Official Full Name
fibroblast growth factor 10
NCBI Official Synonym Full Names
fibroblast growth factor 10
NCBI Official Symbol
FGF10
UniProt Protein Name
Fibroblast growth factor 10
UniProt Synonym Protein Names
Keratinocyte growth factor 2
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF10
UniProt Synonym Gene Names
FGF-10
UniProt Entry Name
FGF10_HUMAN
NCBI Protein Information
fibroblast growth factor 10

NCBI Summary for FGF10

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF10

FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Cell development/differentiation; Secreted

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: cell surface; extracellular matrix; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: chemoattractant activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; protein binding; type 2 fibroblast growth factor receptor binding

Biological Process: actin cytoskeleton reorganization; activation of MAPK activity; activation of MAPKK activity; angiogenesis; axon guidance; blood vessel remodeling; branching morphogenesis of a tube; determination of left/right symmetry; embryonic camera-type eye development; embryonic digestive tract morphogenesis; embryonic genitalia morphogenesis; embryonic pattern specification; epidermal growth factor receptor signaling pathway; epithelial cell proliferation; establishment of mitotic spindle orientation; female genitalia morphogenesis; fibroblast growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; hair follicle morphogenesis; induction of an organ; induction of positive chemotaxis; innate immune response; insulin receptor signaling pathway; keratinocyte proliferation; lacrimal gland development; limb bud formation; male genitalia morphogenesis; MAPKKK cascade; mesonephros development; metanephros development; muscle cell fate commitment; negative regulation of cell differentiation; negative regulation of cell proliferation; nerve growth factor receptor signaling pathway; odontogenesis of dentine-containing teeth; otic vesicle formation; pancreas development; phosphoinositide-mediated signaling; pituitary gland development; positive chemotaxis; positive regulation of ATPase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of fibroblast proliferation; positive regulation of keratinocyte migration; positive regulation of lymphocyte proliferation; positive regulation of MAPKKK cascade; positive regulation of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of urothelial cell proliferation; positive regulation of vascular endothelial growth factor receptor signaling pathway; radial glial cell differentiation; Ras protein signal transduction; regulation of activin receptor signaling pathway; regulation of saliva secretion; regulation of smoothened signaling pathway; response to estradiol stimulus; response to lipopolysaccharide; salivary gland development; small GTPase mediated signal transduction; smooth muscle cell differentiation; somatic stem cell maintenance; spleen development; thymus development; thyroid gland development; tissue regeneration; urothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; white fat cell differentiation; wound healing

Disease: Aplasia Of Lacrimal And Salivary Glands; Lacrimoauriculodentodigital Syndrome
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Research Articles on FGF10

1. FGF10 has a role in protecting neuron against oxygen-glucose deprivation injury through inducing heme oxygenase-1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF10 recombinant protein

 Reference Product  PubMed Publications
 SHH recombinant protein  >106 publications with FGF10 and SHH
 FGFR1 recombinant protein  >58 publications with FGF10 and FGFR1
 FGFR3 recombinant protein  >21 publications with FGF10 and FGFR3
 PDX1 recombinant protein  >13 publications with FGF10 and PDX1
 FGFR4 recombinant protein  >11 publications with FGF10 and FGFR4
 NOTCH1 recombinant protein  >7 publications with FGF10 and NOTCH1
 PTF1A recombinant protein  >4 publications with FGF10 and PTF1A
 PTCH1 recombinant protein  >4 publications with FGF10 and PTCH1

Pathways associated with FGF10 recombinant protein

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with FGF10 recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >41 publications with FGF10 and Disease Models, Animal
 Lung Diseases Antibodies  >32 publications with FGF10 and Lung Diseases
 Cleft Palate Antibodies  >31 publications with FGF10 and Cleft Palate
 Inflammation Antibodies  >23 publications with FGF10 and Inflammation
 Skin Diseases Antibodies  >17 publications with FGF10 and Skin Diseases
 Embryo Loss Antibodies  >17 publications with FGF10 and Embryo Loss
 Cardiovascular Abnormalities Antibodies  >16 publications with FGF10 and Cardiovascular Abnormalities
 Lung Neoplasms Antibodies  >15 publications with FGF10 and Lung Neoplasms
 Heart Defects, Congenital Antibodies  >14 publications with FGF10 and Heart Defects, Congenital
 Fibrosis Antibodies  >14 publications with FGF10 and Fibrosis

Organs/Tissues associated with FGF10 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >61 publications with FGF10 and Muscle
 Brain Antibodies  >48 publications with FGF10 and Brain
 Intestine Antibodies  >34 publications with FGF10 and Intestine
 Kidney Antibodies  >28 publications with FGF10 and Kidney
 Trachea Antibodies  >23 publications with FGF10 and Trachea
 Uterus Antibodies  >10 publications with FGF10 and Uterus
 Mixed Antibodies  >6 publications with FGF10 and Mixed
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