HDAC4 Antibody – Rabbit Polyclonal

Rabbit polyclonal to Human HDAC4

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).

1. Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703. 2. Gregory, P.D. et al. (2001) Exp Cell Res 265, 195-202. 3. Liu, Y. et al. (2000) Mol Cell Biol 20, 5540-53. 4. Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16. 5. Gray, S.G. and Ekström, T.J. (2001) Exp Cell Res 262, 75-83. 6. Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100. 7. Vigushin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218.

Small volumes of anti-HDAC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125288 is an antibody targeting HDAC4. Also known as HDAC4 Rabbit pab Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.