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ACADS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS125363
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This gene encodes a a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated… More details

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Product Overview

Online Datasheet in PDF
Product Name
ACADS, Polyclonal Antibody
Full Product Name
ACADS Polyclonal Antibody
Product Gene Name
anti-ACADS antibody
Product Synonym Names
ACAD3; SCAD
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
412
OMIM
phenotype 606885
3D Structure
ModBase 3D Structure for P16219
Species
Human
Immunogen
Fusion protein of human ACADS
Calculated Molecular Weight
44kDa

Product Categories/Family for anti-ACADS antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ACADS antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACADS antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:100

Western Blot (WB) of anti-ACADS antibody

Western blot analysis of extracts of various cell lines, using ACADS antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 15s.
Rabbit Anti-ACADS Polyclonal Antibody – Cat# MBS125363

Immunohistochemistry (IHC) of anti-ACADS antibody

Immunohistochemistry of paraffin-embedded human liver cancer using ACADS antibody at dilution of 1:100 (40x lens).
Rabbit Anti-ACADS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS125363

Immunohistochemistry (IHC) of anti-ACADS antibody

Immunohistochemistry of paraffin-embedded human liver injury using ACADS antibody at dilution of 1:100 (40x lens).
Rabbit Anti-ACADS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS125363

Immunofluorescence (IF) of anti-ACADS antibody

Immunofluorescence analysis of U2OS cells using ACADS antibody. Blue: DAPI for nuclear staining.
Rabbit Anti-ACADS Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS125363

Other Notes

Small volumes of anti-ACADS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACADS purchase

MBS125363 is an antibody targeting ACADS. Also known as ACADS Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACADS. It may not necessarily be applicable to this product.

NCBI GI #
113019
NCBI GeneID
35
NCBI Accession #
P16219.1
UniProt Primary Accession #
P16219
UniProt Secondary Accession #
P78331
UniProt Related Accession #
P16219
NCBI Official Full Name
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
acyl-CoA dehydrogenase, C-2 to C-3 short chain
NCBI Official Symbol
ACADS
NCBI Official Synonym Symbols
SCAD; ACAD3
UniProt Protein Name
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Synonym Protein Names
Butyryl-CoA dehydrogenase
Protein Family
Short-chain specific acyl-CoA dehydrogenase
UniProt Gene Name
ACADS
UniProt Synonym Gene Names
SCAD
UniProt Entry Name
ACADS_HUMAN
NCBI Protein Information
short-chain specific acyl-CoA dehydrogenase, mitochondrial; butyryl-CoA dehydrogenase; unsaturated acyl-CoA reductase; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; mitochondrial short-chain specific acyl-CoA dehydrogenase

NCBI Summary for ACADS

This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
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UniProt Comments for ACADS

ACADS: Defects in ACADS are the cause of acyl-CoA dehydrogenase short-chain deficiency (ACADSD). It is an autosomal recessive disorder resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in adults. Belongs to the acyl-CoA dehydrogenase family.

Protein type: Lipid Metabolism - fatty acid; Mitochondrial; Carbohydrate Metabolism - butanoate; Oxidoreductase; EC 1.3.8.1; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial membrane; nucleus

Molecular Function: acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; FAD binding; acyl-CoA binding

Biological Process: response to starvation; fatty acid beta-oxidation; response to glucocorticoid stimulus; cellular lipid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; butyrate catabolic process; protein homotetramerization

Disease: Acyl-coa Dehydrogenase, Short-chain, Deficiency Of
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Research Articles on ACADS

1. IVD mutations in Asian populations are distinct from these in Western populations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACADS antibody

 Reference Product  PubMed Publications
 ECHS1 antibody  >3 publications with ACADS and ECHS1
 ACAA2 antibody  >2 publications with ACADS and ACAA2
 ACSM3 antibody  >1 publications with ACADS and ACSM3
 GCDH antibody  >1 publications with ACADS and GCDH
 ACAT2 antibody  >1 publications with ACADS and ACAT2
 EHHADH antibody  >1 publications with ACADS and EHHADH
 ACAT1 antibody  >1 publications with ACADS and ACAT1

Pathways associated with anti-ACADS antibody

 Products by Pathway  Pathway Diagram
 Beta Oxidation Of Butanoyl-CoA To Acetyl-CoA Pathway antibodies  Beta Oxidation Of Butanoyl-CoA To Acetyl-CoA Pathway Diagram
 Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway antibodies  Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram

Diseases associated with anti-ACADS antibody

 Disease Name  Pubmed Publications
 Short chain Acyl CoA dehydrogenase deficiency Antibodies  >9 publications with ACADS and Short chain Acyl CoA dehydrogenase deficiency
 Fatty Liver Antibodies  >6 publications with ACADS and Fatty Liver
 Liver Diseases Antibodies  >5 publications with ACADS and Liver Diseases
 Death Antibodies  >4 publications with ACADS and Death
 Brain Diseases Antibodies  >4 publications with ACADS and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with ACADS and Nervous System Diseases
 Heart Diseases Antibodies  >2 publications with ACADS and Heart Diseases
 Fatty Liver, Alcoholic Antibodies  >1 publications with ACADS and Fatty Liver, Alcoholic
 Disease Models, Animal Antibodies  >1 publications with ACADS and Disease Models, Animal
 Hyperplasia Antibodies  >1 publications with ACADS and Hyperplasia

Organs/Tissues associated with anti-ACADS antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with ACADS and Liver
 Muscle Antibodies  >8 publications with ACADS and Muscle
 Brain Antibodies  >7 publications with ACADS and Brain
 Blood Antibodies  >6 publications with ACADS and Blood
 Kidney Antibodies  >3 publications with ACADS and Kidney
 Connective Tissue Antibodies  >3 publications with ACADS and Connective Tissue
 Nerve Antibodies  >2 publications with ACADS and Nerve
 Prostate Antibodies  >1 publications with ACADS and Prostate
 Skin Antibodies  >1 publications with ACADS and Skin
 Intestine Antibodies  >1 publications with ACADS and Intestine
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