CDK2 Antibody – Rabbit Polyclonal

Cyclin-dependent kinase 2 (p33CDK2) is an important component of the cell cycle machinery. Like p34cdc2, kinase activity is regulated by phosphorylation state as well as association with a cyclin subunit and a CDK inhibitor. Inhibitory phosphorylation occurs on Thr14 and Tyr15 (1). Inhibition of CDK2-cyclin complexes can also be attributed to association with p27 Kip1 and p21 Waf1/Cip1 (2). Activation of CDK2 complexes requires dephosphorylation of Thr14 and Tyr15 by cdc25 phosphatase and phosphorylation of Thr160 (3), which is mediated by CAK, a complex of CDK7 and cyclin H (4). CDK2-cyclin E kinase activity is important for the G1 to S transition and phosphorylation of the Rb protein. During Sphase, active CDK2-cyclin A complexes predominate and phosphorylate E2F and the active CDK2 complex persists in the nucleus throughout G2 (5).

1. Morgan, D.O. (1995) Nature 374, 131-134. 2. Poon, R.Y. et al. (1996) J. Biol. Chem. 271, 13283-13291. 3. Gu, Y. et al. (1992) EMBO J. 11, 3995-4005. 4. Fesquet, D. et al. (1993) EMBO J. 12, 3111-3121. 5. Morgan, D.O. (1997) Annu. Rev. Cell Dev. Biol. 13, 261-291.

Small volumes of anti-CDK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125805 is an antibody targeting CDK2. Also known as CDK2 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.