AKR1C3 Antibody – Goat Polyclonal

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

AKR1C3: Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. Belongs to the aldo/keto reductase family.

Protein type: Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - arachidonic acid; EC 1.1.1.149

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: cytoplasm; cytosol; intracellular; nucleus

Molecular Function: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; aldehyde reductase activity; aldo-keto reductase activity; delta4-3-oxosteroid 5beta-reductase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; ketoreductase activity; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; prostaglandin-F synthase activity; retinal dehydrogenase activity; retinol dehydrogenase activity; testosterone 17-beta-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Biological Process: cellular response to starvation; cyclooxygenase pathway; farnesol catabolic process; G-protein coupled receptor protein signaling pathway; keratinocyte differentiation; male gonad development; multicellular organismal macromolecule metabolic process; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; progesterone metabolic process; prostaglandin metabolic process; protein import into nucleus, translocation; regulation of retinoic acid receptor signaling pathway; response to nutrient; retinal metabolic process; retinoid metabolic process; retinol metabolic process; steroid metabolic process