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Toll-Like Receptor 8 (TLR8) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265273

This protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.… More details

$295 / 0.02 mg (Yeast) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Toll-like receptor 8 (TLR8), Recombinant Protein
Full Product Name
Recombinant Human Toll-like receptor 8 (TLR8) , partial
Product Gene Name
TLR8 recombinant protein
Product Synonym Gene Name
TLR8
Sequence
EENFSRSYPC DEKKQNDSVI AECSNRRLQE VPQTVGKYVT ELDLSDNFIT HITNESFQGL QNLTKINLNH NPNVQHQNGN PGIQSNGLNI TDGAFLNLKN LRELLLEDNQ LPQIPSGLPE SLTELSLIQN NIYNITKEGI SRLINLKNLY LAWNCYFNKV CEKTNIEDGV FETLTNLELL SLSFNSLSHV PPKLPSSLRK LFLSNTQIKY ISEEDFKGLI NLTLLDLSGN CPRCFNAPFP CVPCDGGASI NIDRFAFQNL TQLRYLNLSS TSLRKINAAW FKNMPHLKVL DLEFNYLVGE IASGAFLTML PRLEILDLSF NYIKGSYPQH INISRNFSKL LSLRALHLRG YVFQELREDD FQPLMQLPNL STINLGINFI KQIDFKLFQN FSNLEIIYLS ENRISPLVKD TRQSYANSSS FQRHIRKRRS TDFEFDPHSN FYHFTRPLIK PQCAAYGKAL DLSLNSIFFI GPNQFENLPD IACLNLSANS NAQVLSGTEF SAIPHVKYLD LTNNRLDFDN ASALTELSDL EVLDLSYNSH YFRIAGVTHH LEFIQNFTNL KVLNLSHNNI YTLTDKYNLE SKSLVELVFS GNRLDILWND DDNRYISIFK GLKNLTRLDL SLNRLKHIPN EAFLNLPASL TELHINDNML KFFNWTLLQQ FPRLELLDLR GNKLLFLTDS LSDFTSSLRT LLLSHNRISH LPSGFLSEVS SLKHLDLSSN LLKTINKSAL ETKTTTKLSM LELHGNPFEC TCDIGDFRRW MDEHLNVKIP RLVDVICASP GDQRGKSIVS LELTTCVSDV T
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
93.5 kDa
Sequence Positions
27-827aa, Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
300366
3D Structure
ModBase 3D Structure for Q9NR97
Species
Human

Product Categories/Family for TLR8 recombinant protein

Immunology
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of TLR8 recombinant protein

Human TLR8 Recombinant Protein – Cat# MBS1265273

Other Notes

Small volumes of TLR8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLR8 purchase

MBS1265273 is a recombinant protein targeting TLR8. Also known as Recombinant Human Toll-like receptor 8 (TLR8) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TLR8. It may not necessarily be applicable to this product.

NCBI GI #
20302166
NCBI GeneID
51311
NCBI Accession #
NP_057694.2
UniProt Primary Accession #
Q9NR97
UniProt Secondary Accession #
Q495P4; Q6UXL6; Q9NYG9; B3Y654; D1CS70; D1CS76
UniProt Related Accession #
Q9NR97
GenBank Nucleotide #
NM_016610.3
NCBI Official Full Name
toll-like receptor 8 isoform 1
NCBI Official Synonym Full Names
toll like receptor 8
NCBI Official Symbol
TLR8
NCBI Official Synonym Symbols
CD288
UniProt Protein Name
Toll-like receptor 8
UniProt Synonym Protein Names
CD_antigen: CD288
Protein Family
Toll-like receptor
UniProt Gene Name
TLR8
NCBI Protein Information
toll-like receptor 8

NCBI Summary for TLR8

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
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UniProt Comments for TLR8

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Research Articles on TLR8

1. the current study shows that motolimod ( selective small-molecule agonist of TLR8, stimulates natural killer (NK) cells, dendritic cells, and monocytes))can be safely administered in combination with cetuximab with an acceptable toxicity profile

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TLR8 recombinant protein

 Reference Product  PubMed Publications
 TLR7 recombinant protein  >446 publications with TLR8 and TLR7
 TLR9 recombinant protein  >228 publications with TLR8 and TLR9
 TLR3 recombinant protein  >221 publications with TLR8 and TLR3
 MYD88 recombinant protein  >71 publications with TLR8 and MYD88
 CD40 recombinant protein  >16 publications with TLR8 and CD40
 UNC93B1 recombinant protein  >8 publications with TLR8 and UNC93B1

Pathways associated with TLR8 recombinant protein

 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 Regulation Of Toll-like Receptor Signaling Pathway antibodies  Regulation Of Toll-like Receptor Signaling Pathway Diagram
 TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway antibodies  TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway Diagram
 TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway antibodies  TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway Diagram
 Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway antibodies  Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway Diagram
 Toll Like Receptor 9 (TLR9) Cascade Pathway antibodies  Toll Like Receptor 9 (TLR9) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram

Diseases associated with TLR8 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >119 publications with TLR8 and Inflammation
 Necrosis Antibodies  >90 publications with TLR8 and Necrosis
 Skin Diseases Antibodies  >27 publications with TLR8 and Skin Diseases
 Lung Diseases Antibodies  >22 publications with TLR8 and Lung Diseases
 Death Antibodies  >14 publications with TLR8 and Death
 Heart Diseases Antibodies  >11 publications with TLR8 and Heart Diseases
 Skin Neoplasms Antibodies  >10 publications with TLR8 and Skin Neoplasms
 Kidney Diseases Antibodies  >9 publications with TLR8 and Kidney Diseases
 Fibrosis Antibodies  >7 publications with TLR8 and Fibrosis
 Uterine Cervical Neoplasms Antibodies  >4 publications with TLR8 and Uterine Cervical Neoplasms

Organs/Tissues associated with TLR8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >300 publications with TLR8 and Blood
 Lung Antibodies  >36 publications with TLR8 and Lung
 Spleen Antibodies  >27 publications with TLR8 and Spleen
 Brain Antibodies  >22 publications with TLR8 and Brain
 Kidney Antibodies  >21 publications with TLR8 and Kidney
 Intestine Antibodies  >15 publications with TLR8 and Intestine
 Vascular Antibodies  >12 publications with TLR8 and Vascular
 Uterus Antibodies  >9 publications with TLR8 and Uterus
 Placenta Antibodies  >5 publications with TLR8 and Placenta
 Connective Tissue Antibodies  >3 publications with TLR8 and Connective Tissue
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