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CD31 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS215171

Mouse anti Human CD31 monoclonal antibody, clone WM59 recognizes the human CD31 antigen, a ~130kD single pass type I transmembrane glycoprotein bearing six C2 immunoglobulin domains. CD31 is expressed by all continuous endothelia including arteries, veins and… More details

$245 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD31, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD31
Product Gene Name
anti-CD31 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
WM59
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
81,378 Da
OMIM
173445
3D Structure
ModBase 3D Structure for P16284
Perservative Stabilisers
0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-CD31 antibody
Flow cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD31 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100

Testing Data of anti-CD31 antibody

Staining of human peripheral blood platelets with Mouse anti Human CD31:FITC (MBS210760)
Mouse Anti-CD31 Monoclonal Antibody – Cat# MBS215171

Testing Data of anti-CD31 antibody

Staining of human peripheral blood platelets with Mouse anti Human CD31:Biotin (MBS210356)
Mouse Anti-CD31 Monoclonal Antibody, Testing Data – Cat# MBS215171

Testing Data of anti-CD31 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD31: Alexa Fluor 647 (MBS212289A647)
Mouse Anti-CD31 Monoclonal Antibody, Testing Data – Cat# MBS215171

Testing Data of anti-CD31 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD31 (MBS212289)
Mouse Anti-CD31 Monoclonal Antibody, Testing Data – Cat# MBS215171

Testing Data of anti-CD31 antibody

Staining of human peripheral blood platelets with Mouse anti Human CD31:RPE (MBS213658)
Mouse Anti-CD31 Monoclonal Antibody, Testing Data – Cat# MBS215171

Other Notes

Small volumes of anti-CD31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD31 purchase

MBS215171 is an antibody targeting CD31. Also known as MOUSE ANTI HUMAN CD31. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD31. It may not necessarily be applicable to this product.

NCBI GI #
313760624
NCBI GeneID
5175
NCBI Accession #
NP_000433.4
UniProt Primary Accession #
P16284
UniProt Secondary Accession #
Q6LDA9; Q8TBH1; Q96RF5; Q96RF6; Q9NP65; Q9NPB7; Q9NPG9; Q9NQS9; Q9NQT0; A8K3S7; D3DU31
UniProt Related Accession #
P16284
GenBank Nucleotide #
NM_000442.4
NCBI Official Full Name
platelet endothelial cell adhesion molecule
NCBI Official Synonym Full Names
platelet/endothelial cell adhesion molecule 1
NCBI Official Symbol
PECAM1
NCBI Official Synonym Symbols
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
UniProt Protein Name
Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names
EndoCAM; GPIIA'; PECA1; CD_antigen: CD31
Protein Family
Platelet endothelial cell adhesion molecule
UniProt Gene Name
PECAM1
UniProt Synonym Gene Names
PECAM-1
UniProt Entry Name
PECA1_HUMAN
NCBI Protein Information
platelet endothelial cell adhesion molecule; CD31 antigen

NCBI Summary for CD31

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
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UniProt Comments for CD31

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; platelet alpha granule membrane; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; signal transduction; cell adhesion; blood coagulation; leukocyte migration; phagocytosis
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Research Articles on CD31

1. The finding that the adhesive properties of PECAM-1 are regulatable suggests novel approaches for controlling endothelial cell migration and barrier function in a variety of vascular permeability disorders.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD31 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram

Diseases associated with anti-CD31 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >635 publications with CD31 and Cardiovascular Diseases
 Inflammation Antibodies  >511 publications with CD31 and Inflammation
 Necrosis Antibodies  >406 publications with CD31 and Necrosis
 Neoplasms, Experimental Antibodies  >264 publications with CD31 and Neoplasms, Experimental
 Lung Diseases Antibodies  >247 publications with CD31 and Lung Diseases
 Heart Diseases Antibodies  >235 publications with CD31 and Heart Diseases
 Breast Neoplasms Antibodies  >209 publications with CD31 and Breast Neoplasms
 Lung Neoplasms Antibodies  >193 publications with CD31 and Lung Neoplasms
 Liver Diseases Antibodies  >181 publications with CD31 and Liver Diseases
 Liver Neoplasms Antibodies  >157 publications with CD31 and Liver Neoplasms

Organs/Tissues associated with anti-CD31 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3448 publications with CD31 and Vascular
 Blood Antibodies  >3038 publications with CD31 and Blood
 Muscle Antibodies  >696 publications with CD31 and Muscle
 Embryonic Tissue Antibodies  >512 publications with CD31 and Embryonic Tissue
 Lung Antibodies  >443 publications with CD31 and Lung
 Heart Antibodies  >359 publications with CD31 and Heart
 Skin Antibodies  >343 publications with CD31 and Skin
 Brain Antibodies  >325 publications with CD31 and Brain
 Connective Tissue Antibodies  >249 publications with CD31 and Connective Tissue
 Kidney Antibodies  >240 publications with CD31 and Kidney
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