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C-C Motif Chemokine 4 (CCL4) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265373

MBS1265373 is a recombinant protein targeting Ccl4. Also known as Recombinant Mouse C-C motif chemokine 4. Host: E Coli. Monokine with inflammatory and chokinetic properties. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
C-C motif chemokine 4 (Ccl4), Recombinant Protein
Full Product Name
Recombinant Mouse C-C motif chemokine 4
Product Gene Name
Ccl4 recombinant protein
Product Synonym Gene Name
Mip1b; Scya4
Product Synonym Names
Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4
Sequence
APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKRGRQI CANPSEPWVT EYMSDLELN
Host
E Coli
Form/Format
Liquid containing glycerol
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
11.9kD
Sequence Positions
24-92
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P14097

Product Categories/Family for Ccl4 recombinant protein

Immunology
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of Ccl4 recombinant protein

Mouse CCL4 Recombinant Protein – Cat# MBS1265373

Product References and Citations for Ccl4 recombinant protein

Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta.Sherry B., Tekamp-Olson P., Gallegos C., Bauer D., Davatelis G., Wolpe S.D., Masiarz F., Coit D., Cerami A.J. Exp. Med. 168:2251-2259(1988) A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.J. Immunol. 142:679-687(1989) Sequence of the murine macrophage inflammatory protein 1b gene.Daubersies P., Lepretre F., Bailleul B., Grove M., Pragnell I., Plumb M.A. Sequence polymorphisms in the chemokines Scya1 (TCA-3) , Scya2 (monocyte chemoattractant protein (MCP) -1) , and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.J. Immunol. 163:2262-2266(1999)

Other Notes

Small volumes of Ccl4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Ccl4. It may not necessarily be applicable to this product.

NCBI GI #
7305459
NCBI GeneID
20303
NCBI Accession #
NP_038680.1
UniProt Primary Accession #
P14097
UniProt Related Accession #
P14097
GenBank Nucleotide #
NM_013652.2
NCBI Official Full Name
C-C motif chemokine 4
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 4
NCBI Official Symbol
Ccl4
NCBI Official Synonym Symbols
Act-2; Mip1b; Scya4; MIP-1B; AT744.1
UniProt Protein Name
C-C motif chemokine 4
UniProt Synonym Protein Names
Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4
Protein Family
C-C motif chemokine
UniProt Gene Name
Ccl4
UniProt Synonym Gene Names
Mip1b; Scya4; ACT-2; ACT2; MIP-1-beta
UniProt Entry Name
CCL4_MOUSE
NCBI Protein Information
C-C motif chemokine 4

UniProt Comments for Ccl4

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemokine activity; cytokine activity; identical protein binding; protein binding

Biological Process: chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; leukocyte chemotaxis; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of tumor necrosis factor production; positive regulation of vascular permeability; response to toxin
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Research Articles on Ccl4

1. The chemokines monocyte chemotactic protein 1 (MCP1), MIP1alpha, MIP1beta, interferon gamma-induced protein 10 (IP-10), and eotaxin were induced in Saa1 TG mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Ccl4 recombinant protein

 Reference Product  PubMed Publications
 Ccl3 recombinant protein  >1671 publications with Ccl4 and Ccl3
 Ccl5 recombinant protein  >1029 publications with Ccl4 and Ccl5
 Tnf recombinant protein  >638 publications with Ccl4 and Tnf
 Ccr5 recombinant protein  >609 publications with Ccl4 and Ccr5
 Ccr1 recombinant protein  >201 publications with Ccl4 and Ccr1
 Ccr2 recombinant protein  >112 publications with Ccl4 and Ccr2
 Ccl7 recombinant protein  >82 publications with Ccl4 and Ccl7
 Cxcr3 recombinant protein  >76 publications with Ccl4 and Cxcr3
 Ccr7 recombinant protein  >53 publications with Ccl4 and Ccr7
 Ccbp2 recombinant protein  >1 publications with Ccl4 and Ccbp2

Pathways associated with Ccl4 recombinant protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with Ccl4 recombinant protein

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2935 publications with Ccl4 and Liver Diseases
 Poisoning Antibodies  >2133 publications with Ccl4 and Poisoning
 Drug-Induced Liver Injury Antibodies  >1757 publications with Ccl4 and Drug-Induced Liver Injury
 Disease Models, Animal Antibodies  >1377 publications with Ccl4 and Disease Models, Animal
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1308 publications with Ccl4 and Drug-Related Side Effects and Adverse Reactions
 Necrosis Antibodies  >1304 publications with Ccl4 and Necrosis
 Inflammation Antibodies  >1224 publications with Ccl4 and Inflammation
 Fibrosis Antibodies  >1127 publications with Ccl4 and Fibrosis
 Lung Diseases Antibodies  >273 publications with Ccl4 and Lung Diseases
 Respiratory Tract Diseases Antibodies  >269 publications with Ccl4 and Respiratory Tract Diseases

Organs/Tissues associated with Ccl4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >320 publications with Ccl4 and Bone Marrow
 Spleen Antibodies  >229 publications with Ccl4 and Spleen
 Skin Antibodies  >149 publications with Ccl4 and Skin
 Eye Antibodies  >69 publications with Ccl4 and Eye
 Uncharacterized Tissue Antibodies  >1 publications with Ccl4 and Uncharacterized Tissue
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