Human HPSE2 cDNA Clone Expression Plasmid – Cat# MBS1268922

HPSE2 cDNA Clone – Heparanase 2 (Human)

Name: HPSE2 cDNA Clone; Heparanase 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1268922
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268922

MBS1268922 is a cDNA clone targeting HPSE2. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HPSE2, cDNA Clone

Full Product Name

HPSE2 cDNA Clone

Product Gene Name

HPSE2 cdna clone

Sequence

ATGAGGGTGC TTTGTGCCTT CCCTGAAGCC ATGCCCTCCA GCAACTCCCG CCCCCCCGCG TGCCTAGCCC CGGGGGCTCT CTACTTGGCT CTGTTGCTCC ATCTCTCCCT TTCCTCCCAG GCTGGAGACA GGAGACCCTT GCCTGTAGAC AGAGCTGCAG GTTTGAAGGA AAAGACCCTG ATTCTACTTG ATGTGAGCAC CAAGAACCCA GTCAGGACAG TCAATGAGAA CTTCCTCTCT CTGCAGCTGG ATCCGTCCAT CATTCATGAT GGCTGGCTCG ATTTCCTAAG CTCCAAGCGC TTGGTGACCC TGGCCCGGGG ACTTTCGCCC GCCTTTCTGC GCTTCGGGGG CAAAAGGACC GACTTCCTGC AGTTCCAGAA CCTGAGGAAC CCGGCGAAAA GCCGCGGGGG CCCGGGCCCG GATTACTATC TCAAAAACTA TGAGGATGAC ATTGTTCGAA GTGATGTTGC CTTAGATAAA CAGAAAGGCT GCAAGATTGC CCAGCACCCT GATGTTATGC TGGAGCTCCA AAGGGAGAAG GCAGCTCAGA TGCATCTGGT TCTTCTAAAG GAGCAATTCT CCAATACTTA CAGTAATCTC ATATTAACAG CCAGGTCTCT AGACAAACTT TATAACTTTG CTGATTGCTC TGGACTCCAC CTGATATTTG CTCTAAATGC ACTGCGTCGT AATCCCAATA ACTCCTGGAA CAGTTCTAGT GCCCTGAGTC TGTTGAAGTA CAGCGCCAGC AAAAAGTACA ACATTTCTTG GGAACTGGGT AATGAGCCAA ATAACTATCG GACCATGCAT GGCCGGGCAG TAAATGGCAG CCAGTTGGGA AAGGATTACA TCCAGCTGAA GAGCCTGTTG CAGCCCATCC GGATTTATTC CAGAGCCAGC TTATATGGCC CTAATATTGG GCGGCCGAGG AAGAATGTCA TCGCCCTCCT AGATGGATTC ATGAAGGTGG CAGGAAGTAC AGTAGATGCA GTTACCTGGC AACATTGCTA CATTGATGGC CGGGTGGTCA AGGTGATGGA CTTCCTGAAA ACTCGCCTGT TAGACACACT CTCTGACCAG ATTAGGAAAA TTCAGAAAGT GGTTAATACA TACACTCCAG GAAAGAAGAT TTGGCTTGAA GGTGTGGTGA CCACCTCAGC TGGAGGCACA AACAATCTAT CCGATTCCTA TGCTGCAGGA TTCTTATGGT TGAACACTTT AGGAATGCTG GCCAATCAGG GCATTGATGT CGTGATACGG CACTCATTTT TTGACCATGG ATACAATCAC CTCGTGGACC AGAATTTTAA CCCATTACCA GACTACTGGC TCTCTCTCCT CTACAAGCGC CTGATCGGCC CCAAAGTCTT GGCTGTGCAT GTGGCTGGGC TCCAGCGGAA GCCACGGCCT GGCCGAGTGA TCCGGGACAA ACTAAGGATT TATGCTCACT GCACAAACCA CCACAACCAC AACTACGTTC GTGGGTCCAT TACACTTTTT ATCATCAACT TGCATCGATC AAGAAAGAAA ATCAAGCTGA CTGGGACTCT CAGAGACAAG CTGGTTCACC AGTACCTGCT GCAGCCCTAT GGGCAGGAGG GCCTAAAGTC CAAGTCAGTG CAACTGAATG GCCAGCCCTT AGTGATGGTG GACGACGGGA CCCTCCCAGA ATTGAAGCCC CGCCCCCTTC GGGCCGGCCG GACATTGGTC ATCCCTCCAG TCACCATGGG CTTTTTTGTG GTCAAGAATG TCAATGCTTT GGCCTGCCGC TACCGATAA

Molecular Weight

53,917 Da

OMIM

236730

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HPSE2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HPSE2. It may not necessarily be applicable to this product.

NCBI GI #

85662623

NCBI GeneID

60495

NCBI Accession #

BC112356

UniProt Secondary Accession #

Q5VUH4; Q5VUH5; Q5VUH6; Q8WWQ1; Q9HB37; Q9HB38; Q9HB39

UniProt Related Accession #

Q8WWQ2

NCBI Official Full Name

Homo sapiens heparanase 2, mRNA

NCBI Official Synonym Full Names

heparanase 2 (inactive)

NCBI Official Symbol

HPSE2

NCBI Official Synonym Symbols

UFS; HPA2; HPR2; UFS1

UniProt Protein Name

Inactive heparanase-2

Protein Family

Inactive heparanase

UniProt Gene Name

HPSE2

UniProt Synonym Gene Names

HPA2; Hpa2

UniProt Entry Name

HPSE2_HUMAN

NCBI Protein Information

inactive heparanase-2

NCBI Summary for HPSE2

This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

UniProt Comments for HPSE2

HPSE2: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). Defects in HPSE2 are the cause of urofacial syndrome (UFS). A rare autosomal recessive characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. Belongs to the glycosyl hydrolase 79 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.-.-; Hydrolase; Glycan Metabolism - glycosaminoglycan degradation

Chromosomal Location of Human Ortholog: 10q23-q24

Cellular Component: intracellular; plasma membrane; proteinaceous extracellular matrix

Molecular Function: heparan sulfate proteoglycan binding; heparanase activity

Biological Process: extracellular matrix organization and biogenesis; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process

Disease: Urofacial Syndrome 1

Research Articles on HPSE2

1. Our findings identified these 2 genes as a novel breast cancer biomarker gene set, which may facilitate the diagnosis and treatment in breast cancer clinical therapies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HPSE2 cdna clone

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
HS-GAG Degradation Pathway antibodies	HS-GAG Degradation Pathway Diagram
Heparan Sulfate Degradation Pathway antibodies	Heparan Sulfate Degradation Pathway Diagram
Heparan Sulfate Degradation Pathway antibodies	Heparan Sulfate Degradation Pathway Diagram
Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies	Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram
MPS I - Hurler Syndrome Pathway antibodies	MPS I - Hurler Syndrome Pathway Diagram
MPS II - Hunter Syndrome Pathway antibodies	MPS II - Hunter Syndrome Pathway Diagram

Diseases associated with HPSE2 cdna clone

Disease Name	Pubmed Publications
Urofacial syndrome Antibodies	>8 publications with HPSE2 and Urofacial syndrome
Nervous System Malformations Antibodies	>2 publications with HPSE2 and Nervous System Malformations
Breast Neoplasms Antibodies	>1 publications with HPSE2 and Breast Neoplasms
Uterine Cervical Neoplasms Antibodies	>1 publications with HPSE2 and Uterine Cervical Neoplasms
Inflammation Antibodies	>1 publications with HPSE2 and Inflammation