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Vascular Cell Adhesion Protein 1 (VCAM1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265463

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Vascular cell adhesion protein 1 (Vcam1), Recombinant Protein
Full Product Name
Recombinant Rat Vascular cell adhesion protein 1 (Vcam1), partial
Product Gene Name
Vcam1 recombinant protein
Product Synonym Gene Name
Vcam-1
Product Synonym Names
CD106
Sequence
PEYKTLAQIG DSMLLTCSTT GCESPSFSWR TQIDSPLNGK VKTEGAKSVL TMDPVSFENE HSYLCTATCN SGKLERGIQV DIYSFPKDPE IQFSGPLEVG KPVMVKCLAP DVYPIDRLEI ELFKGDRLMK KQDFVDEMAK KSLETKSLEV IFTPVIEDIE KALVCRAKLY IDQTDSIPKE RETVRELQVY TSPKNTEISV HPSTRLHEGA AVTMTCASEG LPAPEIFWSK KLDNGVLQLL SGNATLTLIA MRMEDSGIYV CEGVNLVGRD KTEVELIVQE KPFTVDISPG SQVAAQVGDS VVLTCAAVGC DSPSFSWRTQ TDSPLNGEVR DEGATSTLTL SPVGVEDEHS YLCTVTCQRR KLEKTIQVEV YSFPEDPEIE ISGPLVHGRP VTVNCTVPNV YPFDHLEIEL LKGETTLLNK FLREEIGTKS LETKSLEMTF IPTAEDTGKA LVCLAKLHSS QMESEPKQRQ STQTLYVNVA PKEPTIWVSP SPVPEEGSPV NLTCSSDGFP TPKILWSRQL KNGELQPLSQ NTTLSFMATK MEDSGIYVCE GINEAGISKK SVELIIQGSS KDIQLTVFPS KSVKEGDTVI ISCTCGSVPE IWIILKKKAK TGDMVLKSVN GSYTIRKAQL QDAGVYECES KTEVGSQLRS LTLDVKGKEN NKDYFSP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
77.4 kDa
Sequence Positions
31-697aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P29534
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of Vcam1 recombinant protein

Rat VCAM1 Recombinant Protein – Cat# MBS1265463

Product References and Citations for Vcam1 recombinant protein

Cloning of murine and rat vascular cell adhesion molecule-1.Hession C., Moy P., Tizard R., Chisholm P., Williams C., Wysk M., Burkly L., Miyake K., Kincade P., Lobb R.Biochem. Biophys. Res. Commun. 183:163-169(1992) Nucleotide sequence of rat vascular cell adhesion molecule-1 cDNA.Williams A.J., Atkins R.C., Fries J.W.U., Gimbrone M.A. Jr., Cybulsky M.I., Collins T.Biochim. Biophys. Acta 1131:214-216(1992)

Other Notes

Small volumes of Vcam1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Vcam1 purchase

MBS1265463 is a recombinant protein targeting Vcam1. Also known as Recombinant Rat Vascular cell adhesion protein 1 (Vcam1), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Vcam1. It may not necessarily be applicable to this product.

NCBI GI #
6981700
NCBI GeneID
25361
NCBI Accession #
NP_037021.1
UniProt Primary Accession #
P29534
UniProt Secondary Accession #
Q5FVS3; Q63669
UniProt Related Accession #
P29534
GenBank Nucleotide #
NM_012889.1
NCBI Official Full Name
vascular cell adhesion protein 1
NCBI Official Synonym Full Names
vascular cell adhesion molecule 1
NCBI Official Symbol
Vcam1
NCBI Official Synonym Symbols
VCAM1B
UniProt Protein Name
Vascular cell adhesion protein 1
UniProt Synonym Protein Names
CD_antigen: CD106
Protein Family
Vascular cell adhesion protein
UniProt Gene Name
Vcam1
UniProt Synonym Gene Names
Vcam-1; V-CAM 1; VCAM-1
UniProt Entry Name
VCAM1_RAT
NCBI Protein Information
vascular cell adhesion protein 1

NCBI Summary for Vcam1

binds integrin very late antigen (VLA4); plays a role in cell adhesion [RGD, Feb 2006]

UniProt Comments for Vcam1

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: apical part of cell; cell surface; early endosome; endoplasmic reticulum; external side of plasma membrane; extracellular space; filopodium; Golgi apparatus; integral to membrane; microvillus; podosome; sarcolemma

Molecular Function: amine oxidase activity; cell adhesion molecule binding; integrin binding

Biological Process: acute inflammatory response; aging; amine metabolic process; cell adhesion; cell-cell adhesion; cell-matrix adhesion; chronic inflammatory response; heart development; heterophilic cell adhesion; leukocyte adhesion; leukocyte tethering or rolling; membrane to membrane docking; positive regulation of T cell proliferation; response to ethanol; response to hypoxia; response to ionizing radiation; response to lipopolysaccharide; response to nicotine; response to nutrient; response to zinc ion; viral reproduction
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Research Articles on Vcam1

1. Activation of Wnt/beta-catenin signaling in AECs attenuated intercellular adhesion molecule 1 (ICAM-1)/vascular cell adhesion molecule 1 (VCAM-1)-mediated adhesion of both macrophages and neutrophils to AECs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Vcam1 recombinant protein

 Reference Product  PubMed Publications
 Itgb1 recombinant protein  >3 publications with Vcam1 and Itgb1
 Cybb recombinant protein  >2 publications with Vcam1 and Cybb
 Nox1 recombinant protein  >1 publications with Vcam1 and Nox1
 Itga9 recombinant protein  >1 publications with Vcam1 and Itga9

Pathways associated with Vcam1 recombinant protein

 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with Vcam1 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >115 publications with Vcam1 and Inflammation
 Cardiovascular Diseases Antibodies  >73 publications with Vcam1 and Cardiovascular Diseases
 Necrosis Antibodies  >58 publications with Vcam1 and Necrosis
 Atherosclerosis Antibodies  >55 publications with Vcam1 and Atherosclerosis
 Heart Diseases Antibodies  >19 publications with Vcam1 and Heart Diseases
 Kidney Diseases Antibodies  >18 publications with Vcam1 and Kidney Diseases
 Fibrosis Antibodies  >14 publications with Vcam1 and Fibrosis
 Hypertension Antibodies  >13 publications with Vcam1 and Hypertension
 Myocardial Ischemia Antibodies  >10 publications with Vcam1 and Myocardial Ischemia
 Myocardial Infarction Antibodies  >8 publications with Vcam1 and Myocardial Infarction

Organs/Tissues associated with Vcam1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Artery Antibodies  >43 publications with Vcam1 and Artery
 Brain Antibodies  >28 publications with Vcam1 and Brain
 Kidney Antibodies  >27 publications with Vcam1 and Kidney
 Lung Antibodies  >19 publications with Vcam1 and Lung
 Adipose Tissue Antibodies  >7 publications with Vcam1 and Adipose Tissue
 Spleen Antibodies  >6 publications with Vcam1 and Spleen
 Eye Antibodies  >4 publications with Vcam1 and Eye
 Pancreas Antibodies  >3 publications with Vcam1 and Pancreas
 Prostate Antibodies  >2 publications with Vcam1 and Prostate
 Thymus Antibodies  >1 publications with Vcam1 and Thymus
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