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NOX4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127001
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This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
NOX4, Polyclonal Antibody
Full Product Name
NOX4 Polyclonal Antibody
Product Gene Name
anti-NOX4 antibody
Product Synonym Names
KOX; KOX-1; RENOX
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
Molecular Weight
Calculated MW: 6kDa/25-31kDa/58-66kDa
Observed MW: 67 kDa
OMIM
605261
3D Structure
ModBase 3D Structure for Q9NPH5
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 444-578 of human NOX4 (NP_058627.1).

Product Categories/Family for anti-NOX4 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NOX4 antibody
Western Blot (WB)
Application Notes for anti-NOX4 antibody
WB: 1:500 - 1:2000

Western Blot (WB) of anti-NOX4 antibody

Western blot analysis of extracts of various cell lines, using NOX4 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Rabbit Anti-NOX4 Polyclonal Antibody – Cat# MBS127001

Other Notes

Small volumes of anti-NOX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NOX4 purchase

MBS127001 is an antibody targeting NOX4. Also known as NOX4 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NOX4. It may not necessarily be applicable to this product.

NCBI GI #
212276447
NCBI GeneID
50507
NCBI Accession #
Q9NPH5.2
UniProt Primary Accession #
Q9NPH5
UniProt Secondary Accession #
Q5K3R4; Q5K3R5; Q5K3R6; Q5K3R8; Q7Z7G3; Q86V92; A8K715; B7Z520; E7EMD7
UniProt Related Accession #
Q9NPH5
NCBI Official Full Name
NADPH oxidase 4
NCBI Official Synonym Full Names
NADPH oxidase 4
NCBI Official Symbol
NOX4
NCBI Official Synonym Symbols
KOX; KOX-1; RENOX
UniProt Protein Name
NADPH oxidase 4
UniProt Synonym Protein Names
Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase
Protein Family
NADPH oxidase
UniProt Gene Name
NOX4
UniProt Synonym Gene Names
RENOX; KOX-1
UniProt Entry Name
NOX4_HUMAN
NCBI Protein Information
NADPH oxidase 4; kidney oxidase-1; renal NAD(P)H-oxidase; kidney superoxide-producing NADPH oxidase

UniProt Comments for NOX4

NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 1.6.3.-; Membrane protein, multi-pass; Cell cycle regulation; Nucleolus; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q14.2-q21

Cellular Component: endoplasmic reticulum membrane; focal adhesion; mitochondrion; perinuclear region of cytoplasm; apical plasma membrane; nucleolus; integral to membrane; stress fiber; NADPH oxidase complex

Molecular Function: oxygen sensor activity; electron carrier activity; FAD binding; NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; nucleotide binding; heme binding

Biological Process: positive regulation of apoptosis; cell morphogenesis; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; cardiac muscle cell differentiation; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; response to hypoxia; inflammatory response; superoxide release; bone resorption
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Research Articles on NOX4

1. Nox4-mediated redox regulation of PTP1B serves as a modulator, in part through coronin-1C, of the growth and migration of glioblastoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NOX4 antibody

 Reference Product  PubMed Publications
 TGFB1 antibody  >72 publications with NOX4 and TGFB1
 CYBA antibody  >57 publications with NOX4 and CYBA
 TLR4 antibody  >13 publications with NOX4 and TLR4
 AKT1 antibody  >6 publications with NOX4 and AKT1
 PTPN1 antibody  >6 publications with NOX4 and PTPN1
 SRF antibody  >3 publications with NOX4 and SRF
 VEGFA antibody  >3 publications with NOX4 and VEGFA
 MMP1 antibody  >2 publications with NOX4 and MMP1
 IGFBP3 antibody  >1 publications with NOX4 and IGFBP3

Pathways associated with anti-NOX4 antibody

 Products by Pathway  Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Signaling Events Mediated By PTP1B Pathway antibodies  Signaling Events Mediated By PTP1B Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with anti-NOX4 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >256 publications with NOX4 and Cardiovascular Diseases
 Hypertension Antibodies  >168 publications with NOX4 and Hypertension
 Inflammation Antibodies  >158 publications with NOX4 and Inflammation
 Disease Models, Animal Antibodies  >148 publications with NOX4 and Disease Models, Animal
 Fibrosis Antibodies  >139 publications with NOX4 and Fibrosis
 Heart Diseases Antibodies  >109 publications with NOX4 and Heart Diseases
 Atherosclerosis Antibodies  >97 publications with NOX4 and Atherosclerosis
 Kidney Diseases Antibodies  >90 publications with NOX4 and Kidney Diseases
 Hypertrophy Antibodies  >87 publications with NOX4 and Hypertrophy
 Necrosis Antibodies  >63 publications with NOX4 and Necrosis

Organs/Tissues associated with anti-NOX4 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >441 publications with NOX4 and Vascular
 Kidney Antibodies  >193 publications with NOX4 and Kidney
 Brain Antibodies  >55 publications with NOX4 and Brain
 Connective Tissue Antibodies  >40 publications with NOX4 and Connective Tissue
 Eye Antibodies  >32 publications with NOX4 and Eye
 Embryonic Tissue Antibodies  >21 publications with NOX4 and Embryonic Tissue
 Intestine Antibodies  >8 publications with NOX4 and Intestine
 Pancreas Antibodies  >8 publications with NOX4 and Pancreas
 Placenta Antibodies  >5 publications with NOX4 and Placenta
 Mouth Antibodies  >4 publications with NOX4 and Mouth
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