GRIA1 Antibody – Rabbit Polyclonal

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Membrane protein, multi-pass; Channel, calcium; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: postsynaptic membrane; recycling endosome; endoplasmic reticulum membrane; synaptic vesicle; cell surface; cell soma; dendrite; postsynaptic density; plasma membrane; dendritic spine; cell junction

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; glutamate receptor activity; PDZ domain binding

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; long-term memory; ionotropic glutamate receptor signaling pathway; receptor internalization; signal transduction