THRB Antibody – Rabbit Polyclonal

TR-beta1: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Homolog of the viral oncogene erbB. Two splice variant isoforms have been described.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: nucleoplasm; nuclear chromatin; nucleus

Molecular Function: protein binding; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; chromatin DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription corepressor activity; transcription factor activity

Biological Process: negative regulation of female receptivity; transcription initiation from RNA polymerase II promoter; organ morphogenesis; sensory perception of sound; intracellular receptor-mediated signaling pathway; female courtship behavior; transcription, DNA-dependent; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction

Disease: Thyroid Hormone Resistance, Selective Pituitary; Thyroid Hormone Resistance, Generalized, Autosomal Dominant; Thyroid Hormone Resistance, Generalized, Autosomal Recessive