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DLC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127717
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This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DLC1, Polyclonal Antibody
Full Product Name
DLC1 Polyclonal Antibody
Product Gene Name
anti-DLC1 antibody
Product Synonym Names
HP; ARHGAP7; STARD12; p122-RhoGAP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
1528
OMIM
604258
3D Structure
ModBase 3D Structure for Q96QB1
Species
Human
Immunogen
Recombinant protein of human DLC1
Calculated Molecular Weight
171kDa

Product Categories/Family for anti-DLC1 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DLC1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DLC1 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-DLC1 antibody

Western blot analysis of extracts of mouse lung, using DLC1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Rabbit Anti-DLC1 Polyclonal Antibody – Cat# MBS127717

Immunohistochemistry (IHC) of anti-DLC1 antibody

Immunohistochemistry of paraffin-embedded rat kidney using DLC1 antibody at dilution of 1:200 (40x lens).
Rabbit Anti-DLC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127717

Other Notes

Small volumes of anti-DLC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLC1 purchase

MBS127717 is an antibody targeting DLC1. Also known as DLC1 Polyclonal Antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DLC1. It may not necessarily be applicable to this product.

NCBI GI #
313104315
NCBI GeneID
10395
NCBI Accession #
Q96QB1.4
UniProt Primary Accession #
Q96QB1
UniProt Secondary Accession #
O14868; O43199; Q7Z5R8; Q86UC6; Q9C0E0; Q9H7A2; B4DR10; B8PTI0; E9PDZ8; E9PF76; E9PGY9
UniProt Related Accession #
Q96QB1
NCBI Official Full Name
Rho GTPase-activating protein 7
NCBI Official Synonym Full Names
DLC1 Rho GTPase activating protein
NCBI Official Symbol
DLC1
NCBI Official Synonym Symbols
HP; ARHGAP7; STARD12; p122-RhoGAP
UniProt Protein Name
Rho GTPase-activating protein 7
UniProt Synonym Protein Names
Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12
Protein Family
Dynein
UniProt Gene Name
DLC1
UniProt Synonym Gene Names
ARHGAP7; KIAA1723; STARD12; DLC-1; StARD12
UniProt Entry Name
RHG07_HUMAN
NCBI Protein Information
rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; deleted in liver cancer 1 protein; START domain-containing protein 12; deleted in liver cancer 1 variant 2; rho-type GTPase-activating protein 7; StAR-related lipid transfer (START) domain containing 12

UniProt Comments for DLC1

DLC1: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho; Tumor suppressor

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: cortical actin cytoskeleton; focal adhesion; cytoplasm; caveola; cytosol; nucleus

Molecular Function: protein binding; SH2 domain binding; lipid binding

Biological Process: caspase activation; focal adhesion formation; heart morphogenesis; hindbrain morphogenesis; negative regulation of stress fiber formation; apoptosis; negative regulation of focal adhesion formation; positive regulation of protein amino acid dephosphorylation; regulation of cell shape; negative regulation of cell proliferation; regulation of small GTPase mediated signal transduction; negative regulation of Rho protein signal transduction; small GTPase mediated signal transduction; regulation of actin cytoskeleton organization and biogenesis; neural tube closure; forebrain development; actin cytoskeleton organization and biogenesis; negative regulation of cell migration

Disease: Colorectal Cancer
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Research Articles on DLC1

1. DLC-1 is negatively associated with nasopharyngeal carcinoma carcinogenesis, and promoter hypermethylation along with loss of heterozygosity, but not mutation, contributes to inactivation of DLC-1 in nasopharyngeal carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DLC1 antibody

 Reference Product  PubMed Publications
 TENC1 antibody  >8 publications with DLC1 and TENC1
 PAK1 antibody  >6 publications with DLC1 and PAK1
 DYNLL1 antibody  >5 publications with DLC1 and DYNLL1
 RPS6KA1 antibody  >1 publications with DLC1 and RPS6KA1
 CAV1 antibody  >1 publications with DLC1 and CAV1

Pathways associated with anti-DLC1 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram

Diseases associated with anti-DLC1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >92 publications with DLC1 and Carcinoma
 Liver Neoplasms Antibodies  >75 publications with DLC1 and Liver Neoplasms
 Adenocarcinoma Antibodies  >41 publications with DLC1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >38 publications with DLC1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >34 publications with DLC1 and Liver Diseases
 Breast Neoplasms Antibodies  >29 publications with DLC1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >27 publications with DLC1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >24 publications with DLC1 and Lung Neoplasms
 Liver Neoplasms, Experimental Antibodies  >22 publications with DLC1 and Liver Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >16 publications with DLC1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-DLC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >129 publications with DLC1 and Liver
 Lung Antibodies  >30 publications with DLC1 and Lung
 Prostate Antibodies  >22 publications with DLC1 and Prostate
 Kidney Antibodies  >11 publications with DLC1 and Kidney
 Skin Antibodies  >6 publications with DLC1 and Skin
 Brain Antibodies  >6 publications with DLC1 and Brain
 Nerve Antibodies  >5 publications with DLC1 and Nerve
 Stomach Antibodies  >5 publications with DLC1 and Stomach
 Bone Antibodies  >5 publications with DLC1 and Bone
 Bone Marrow Antibodies  >4 publications with DLC1 and Bone Marrow
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