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MUTYH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127918
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This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively… More details

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Product Overview

Product Name
MUTYH, Polyclonal Antibody
Full Product Name
MUTYH Polyclonal Antibody
Product Gene Name
anti-MUTYH antibody
Product Synonym Names
MYH
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
546
OMIM
phenotype 613659
3D Structure
ModBase 3D Structure for Q9UIF7
Species
Human
Immunogen
Recombinant protein of human MUTYH
Calculated Molecular Weight
60kDa

Product Categories/Family for anti-MUTYH antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MUTYH antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MUTYH antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-MUTYH antibody

Western blot analysis of extracts of various cell lines, using MUTYH antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Rabbit Anti-MUTYH Polyclonal Antibody – Cat# MBS127918

Other Notes

Small volumes of anti-MUTYH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MUTYH purchase

MBS127918 is an antibody targeting MUTYH. Also known as MUTYH Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MUTYH. It may not necessarily be applicable to this product.

NCBI GI #
48428272
NCBI GeneID
4595
NCBI Accession #
Q9UIF7.1
UniProt Primary Accession #
Q9UIF7
UniProt Secondary Accession #
Q15830; Q9UBP2; Q9UBS7; Q9UIF4; Q9UIF5; Q9UIF6; D3DPZ4
UniProt Related Accession #
Q9UIF7
NCBI Official Full Name
A/G-specific adenine DNA glycosylase
NCBI Official Synonym Full Names
mutY homolog
NCBI Official Symbol
MUTYH
NCBI Official Synonym Symbols
MYH
UniProt Protein Name
A/G-specific adenine DNA glycosylase
UniProt Synonym Protein Names
MutY homolog; hMYH
UniProt Gene Name
MUTYH
UniProt Synonym Gene Names
MYH; hMYH
UniProt Entry Name
MUTYH_HUMAN
NCBI Protein Information
A/G-specific adenine DNA glycosylase

UniProt Comments for MUTYH

MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Tumor suppressor; Hydrolase; EC 3.2.2.-; DNA repair, damage

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: nucleoplasm; mitochondrion; nucleus

Molecular Function: protein binding; 4 iron, 4 sulfur cluster binding; metal ion binding; hydrolase activity, acting on glycosyl bonds; MutLalpha complex binding; MutSbeta complex binding; MutLbeta complex binding; MutSalpha complex binding

Biological Process: mismatch repair; depurination; base-excision repair, AP site formation; base-excision repair; DNA repair

Disease: Gastric Cancer; Pilomatrixoma; Familial Adenomatous Polyposis, 2
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Research Articles on MUTYH

1. A heterozygous p.Arg19 * MUTYH variant and a heterozygous p.Arg109Trp MUTYH variant were detected in one patient each.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MUTYH antibody

 Reference Product  PubMed Publications
 OGG1 antibody  >57 publications with MUTYH and OGG1
 MSH6 antibody  >19 publications with MUTYH and MSH6
 APEX1 antibody  >14 publications with MUTYH and APEX1
 PCNA antibody  >7 publications with MUTYH and PCNA
 HUS1 antibody  >4 publications with MUTYH and HUS1
 APEX2 antibody  >2 publications with MUTYH and APEX2
 MLH3 antibody  >1 publications with MUTYH and MLH3

Pathways associated with anti-MUTYH antibody

 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base-Excision Repair, AP Site Formation Pathway antibodies  Base-Excision Repair, AP Site Formation Pathway Diagram
 Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway antibodies  Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway Diagram
 Cleavage Of The Damaged Purine Pathway antibodies  Cleavage Of The Damaged Purine Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Depurination Pathway antibodies  Depurination Pathway Diagram
 Displacement Of DNA Glycosylase By APE1 Pathway antibodies  Displacement Of DNA Glycosylase By APE1 Pathway Diagram
 Recognition And Association Of DNA Glycosylase With Site Containing An Affected Purine Pathway antibodies  Recognition And Association Of DNA Glycosylase With Site Containing An Affected Purine Pathway Diagram

Diseases associated with anti-MUTYH antibody

 Disease Name  Pubmed Publications
 Adenomatous Polyposis Coli Antibodies  >114 publications with MUTYH and Adenomatous Polyposis Coli
 Carcinoma Antibodies  >48 publications with MUTYH and Carcinoma
 Colorectal Adenomatous Polyposis, Autosomal Recessive Antibodies  >34 publications with MUTYH and Colorectal Adenomatous Polyposis, Autosomal Recessive
 Adenocarcinoma Antibodies  >17 publications with MUTYH and Adenocarcinoma
 Lung Neoplasms Antibodies  >13 publications with MUTYH and Lung Neoplasms
 Breast Neoplasms Antibodies  >11 publications with MUTYH and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >7 publications with MUTYH and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >6 publications with MUTYH and Liver Neoplasms
 Inflammation Antibodies  >4 publications with MUTYH and Inflammation
 Stomach Neoplasms Antibodies  >4 publications with MUTYH and Stomach Neoplasms

Organs/Tissues associated with anti-MUTYH antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with MUTYH and Blood
 Lung Antibodies  >14 publications with MUTYH and Lung
 Skin Antibodies  >10 publications with MUTYH and Skin
 Liver Antibodies  >10 publications with MUTYH and Liver
 Intestine Antibodies  >10 publications with MUTYH and Intestine
 Brain Antibodies  >10 publications with MUTYH and Brain
 Thyroid Antibodies  >8 publications with MUTYH and Thyroid
 Stomach Antibodies  >4 publications with MUTYH and Stomach
 Kidney Antibodies  >2 publications with MUTYH and Kidney
 Nerve Antibodies  >2 publications with MUTYH and Nerve
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