Human ACD Recombinant Protein – Cat# MBS1285385

Adrenocortical Dysplasia Protein Homolog (ACD) Human Recombinant Protein

Name: ACD Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1285385
Price: 1355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1285385

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosomeshelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with… More details

$1355 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Adrenocortical dysplasia protein homolog (ACD), Recombinant Protein

Full Product Name

Recombinant Human Adrenocortical dysplasia protein homolog (ACD)

Product Gene Name

ACD recombinant protein

Product Synonym Gene Name

ACD

Sequence

MPGRCQSDAA MRVNGPASRA PAGWTSGSLH TGPRAGRPRA QARGVRGRGL LLRPRPAKEL PLPRKGGAWA PAGNPGPLHP LGVAVGMAGS GRLVLRPWIR ELILGSETPS SPRAGQLLEV LQDAEAAVAG PSHAPDTSDV GATLLVSDGT HSVRCLVTRE ALDTSDWEEK EFGFRGTEGR LLLLQDCGVH VQVAEGGAPA EFYLQVDRFS LLPTEQPRLR VPGCNQDLDV QKKLYDCLEE HLSESTSSNA GLSLSQLLDE MREDQEHQGA LVCLAESCLT LEGPCTAPPV THWAASRCKA TGEAVYTVPS SMLCISENDQ LILSSLGPCQ RTQGPELPPP DPALQDLSLT LIASPPSSPS SSGTPALPGH MSSEESGTSI SLLPALSLAA PDPGQRSSSQ PSPAICSAPA TLTPRSPHAS RTPSSPLQSC TPSLSPRSHV PSPHQALVTR PQKPSLEFKE FVGLPCKNRP PFPRTGATRG AQEPCSVWEP PKRHRDGSAF QYEYEPPCTS LCARVQAVRL PPQLMAWALH FLMDAQPGSE PTPM

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

57,393 Da

Sequence Positions

1-544, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

609377

3D Structure

ModBase 3D Structure for Q96AP0

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ACD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACD purchase

MBS1285385 is a recombinant protein targeting ACD. Also known as Recombinant Human Adrenocortical dysplasia protein homolog (ACD). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ACD. It may not necessarily be applicable to this product.

NCBI GI #

130978956

NCBI GeneID

65057

NCBI Accession #

NP_001075955.1

UniProt Primary Accession #

Q96AP0

UniProt Secondary Accession #

Q562H5; Q9H8F9

UniProt Related Accession #

Q96AP0

GenBank Nucleotide #

NM_001082486.1

NCBI Official Full Name

adrenocortical dysplasia protein homolog isoform 1

NCBI Official Synonym Full Names

ACD, shelterin complex subunit and telomerase recruitment factor

NCBI Official Symbol

ACD

NCBI Official Synonym Symbols

PIP1; PTOP; TPP1; TINT1

UniProt Protein Name

Adrenocortical dysplasia protein homolog

UniProt Synonym Protein Names

POT1 and TIN2-interacting protein

Protein Family

Adrenocortical dysplasia protein

UniProt Gene Name

ACD

UniProt Synonym Gene Names

PIP1; PTOP; TINT1; TPP1

NCBI Protein Information

adrenocortical dysplasia protein homolog

NCBI Summary for ACD

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]

UniProt Comments for ACD

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Research Articles on ACD

1. a novel ACD mutation(p.G223V)is detected; ACD is a novel gene involved in childhood pre-B acute lymphoblastic leukemia and may play a functional role in enhancing leukemia cell survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ACD recombinant protein

Reference Product	PubMed Publications
POT1 recombinant protein	>6 publications with ACD and POT1
TINF2 recombinant protein	>3 publications with ACD and TINF2
LLGL1 recombinant protein	>1 publications with ACD and LLGL1

Pathways associated with ACD recombinant protein

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Chromosome Maintenance Pathway antibodies	Chromosome Maintenance Pathway Diagram
Meiosis Pathway antibodies	Meiosis Pathway Diagram
Meiotic Synapsis Pathway antibodies	Meiotic Synapsis Pathway Diagram
Packaging Of Telomere Ends Pathway antibodies	Packaging Of Telomere Ends Pathway Diagram
Regulation Of Telomerase Pathway antibodies	Regulation Of Telomerase Pathway Diagram
Shelterin Complex Pathway antibodies	Shelterin Complex Pathway Diagram
Telomere Maintenance Pathway antibodies	Telomere Maintenance Pathway Diagram

Diseases associated with ACD recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>172 publications with ACD and Neoplasms
Inflammation Antibodies	>149 publications with ACD and Inflammation
Heart Diseases Antibodies	>125 publications with ACD and Heart Diseases
Nervous System Diseases Antibodies	>121 publications with ACD and Nervous System Diseases
Necrosis Antibodies	>84 publications with ACD and Necrosis
Gastrointestinal Diseases Antibodies	>73 publications with ACD and Gastrointestinal Diseases
Drug Toxicity Antibodies	>55 publications with ACD and Drug Toxicity
Kidney Diseases Antibodies	>49 publications with ACD and Kidney Diseases
Hypertension Antibodies	>44 publications with ACD and Hypertension
Hemorrhage Antibodies	>41 publications with ACD and Hemorrhage

Organs/Tissues associated with ACD recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1150 publications with ACD and Blood
Eye Antibodies	>438 publications with ACD and Eye
Skin Antibodies	>289 publications with ACD and Skin
Bone Antibodies	>167 publications with ACD and Bone
Brain Antibodies	>97 publications with ACD and Brain
Lung Antibodies	>69 publications with ACD and Lung
Liver Antibodies	>65 publications with ACD and Liver
Kidney Antibodies	>60 publications with ACD and Kidney
Muscle Antibodies	>52 publications with ACD and Muscle
Intestine Antibodies	>49 publications with ACD and Intestine