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Protein O-Glucosyltransferase 1 (POGLUT1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1288166

MBS1288166 is a recombinant protein targeting Poglut1. Also known as Recombinant Mouse Protein O-glucosyltransferase 1 (Poglut1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1090 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Protein O-glucosyltransferase 1 (Poglut1), Recombinant Protein
Full Product Name
Recombinant Mouse Protein O-glucosyltransferase 1 (Poglut1)
Product Gene Name
Poglut1 recombinant protein
Product Synonym Gene Name
Poglut1
Sequence
RQKDSGSKWK VFLDQINRAL ENYEPCSSQN CSCYHGVIEE DLTPFRGGIS RKMMAEVVRR KLGTHYQIIK NRLFREDDCM FPSRCSGVEH FILEVIHRLP DMEMVINVRD YPQVPKWMEP TIPVFSFSKT SEYHDIMYPA WTFWEGGPAV WPLYPTGLGR WDLFREDLLR SAAQWPWEKK NSTAYFRGSR TSPERDPLIL LSRKNPKLVD AEYTKNQAWK SMKDTLGKPA AKDVHLIDHC KYRYLFNFRG VAASFRFKHL FLCGSLVFHV GDEWVEFFYP QLKPWVHYIP VKTDLSNVQE LLQFVKANDD IAQEIAKRGS QFIINHLQMD DITCYWENLL TDYSKFLSYN VTRRKDYYQI VPRRLKTEL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
46,379 Da
Sequence Positions
24-392, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8BYB9
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Poglut1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Poglut1. It may not necessarily be applicable to this product.

NCBI GI #
27369505
NCBI GeneID
224143
NCBI Accession #
NP_759012.1
UniProt Primary Accession #
Q8BYB9
UniProt Secondary Accession #
Q8R0H7
UniProt Related Accession #
Q8BYB9
GenBank Nucleotide #
NM_172380.4
NCBI Official Full Name
protein O-glucosyltransferase 1 isoform 1
NCBI Official Synonym Full Names
protein O-glucosyltransferase 1
NCBI Official Symbol
Poglut1
NCBI Official Synonym Symbols
Rumi; wsnp; Clp46; Ktelc1; 9630046K23Rik
UniProt Protein Name
Protein O-glucosyltransferase 1
UniProt Synonym Protein Names
CAP10-like 46 kDa protein; KTEL motif-containing protein 1; O-glucosyltransferase Rumi homolog
Protein Family
Protein O-glucosyltransferase
UniProt Gene Name
Poglut1
UniProt Synonym Gene Names
Wsnp
NCBI Protein Information
protein O-glucosyltransferase 1

NCBI Summary for Poglut1

This gene encodes a protein that can catalyze transfer of either UDP-glucose or UDP-xylose to epidermal growth factor (EGF) repeats, such as those found in Notch. Loss of this gene product results in embryonic lethality. Embryos have neural plate defects, heart defects, and truncations of their posterior axis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for Poglut1

Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21949356, PubMed:26496195). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21949356, PubMed:26496195). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (). Notch glucosylation does not affect Notch ligand binding (). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (PubMed:26496195).
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Research Articles on Poglut1

1. Removing one copy of Rumi suppresses the Jag1(+/-) bile duct phenotype, indicating that Rumi opposes JAG1 function in the liver

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Poglut1 recombinant protein

 Reference Product  PubMed Publications
 Notch1 recombinant protein  >3 publications with Poglut1 and Notch1
 Pofut1 recombinant protein  >3 publications with Poglut1 and Pofut1
 Notch2 recombinant protein  >1 publications with Poglut1 and Notch2

Pathways associated with Poglut1 recombinant protein

 Products by Pathway  Pathway Diagram
 Other Types Of O-glycan Biosynthesis Pathway antibodies  Other Types Of O-glycan Biosynthesis Pathway Diagram
 Other Types Of O-glycan Biosynthesis Pathway antibodies  Other Types Of O-glycan Biosynthesis Pathway Diagram
 Pre-NOTCH Expression And Processing Pathway antibodies  Pre-NOTCH Expression And Processing Pathway Diagram
 Pre-NOTCH Processing In The Endoplasmic Reticulum Pathway antibodies  Pre-NOTCH Processing In The Endoplasmic Reticulum Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By NOTCH Pathway antibodies  Signaling By NOTCH Pathway Diagram

Diseases associated with Poglut1 recombinant protein

 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >1 publications with Poglut1 and Chromosome Aberrations

Organs/Tissues associated with Poglut1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with Poglut1 and Skin
 Intestine Antibodies  >2 publications with Poglut1 and Intestine
 Bone Marrow Antibodies  >2 publications with Poglut1 and Bone Marrow
 Spleen Antibodies  >1 publications with Poglut1 and Spleen
 Thymus Antibodies  >1 publications with Poglut1 and Thymus
 Mammary Gland Antibodies  >1 publications with Poglut1 and Mammary Gland
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