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DYNC1I1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS128835
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MBS128835 is an antibody targeting DYNC1I1. Also known as DYNC1I1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$225 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DYNC1I1, Polyclonal Antibody
Full Product Name
DYNC1I1 Polyclonal Antibody
Product Gene Name
anti-DYNC1I1 antibody
Product Synonym Names
DNCI1; DNCIC1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
645
OMIM
603772
3D Structure
ModBase 3D Structure for O14576
Species
Human
Immunogen
Recombinant protein of human DYNC1I1
Calculated Molecular Weight
71kDa

Product Categories/Family for anti-DYNC1I1 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DYNC1I1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DYNC1I1 antibody
WB: 1:200-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-DYNC1I1 antibody

Western blot analysis of extracts of various cell lines, using DYNC1I1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
Rabbit Anti-DYNC1I1 Polyclonal Antibody – Cat# MBS128835

Immunohistochemistry (IHC) of anti-DYNC1I1 antibody

Immunohistochemistry of paraffin-embedded human stomach using DYNC1I1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-DYNC1I1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS128835

Immunohistochemistry (IHC) of anti-DYNC1I1 antibody

Immunohistochemistry of paraffin-embedded rat brain using DYNC1I1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-DYNC1I1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS128835

Other Notes

Small volumes of anti-DYNC1I1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DYNC1I1. It may not necessarily be applicable to this product.

NCBI GI #
6647481
NCBI GeneID
1780
NCBI Accession #
O14576.2
UniProt Primary Accession #
O14576
UniProt Secondary Accession #
Q8TBF7; Q9Y2X1; B4DME3; F5H050; G5E9K1
UniProt Related Accession #
O14576
NCBI Official Full Name
Cytoplasmic dynein 1 intermediate chain 1
NCBI Official Synonym Full Names
dynein, cytoplasmic 1, intermediate chain 1
NCBI Official Symbol
DYNC1I1
NCBI Official Synonym Symbols
DNCI1; DNCIC1
UniProt Protein Name
Cytoplasmic dynein 1 intermediate chain 1
UniProt Synonym Protein Names
Cytoplasmic dynein intermediate chain 1; Dynein intermediate chain 1, cytosolic; DH IC-1
Protein Family
Cytoplasmic dynein
UniProt Gene Name
DYNC1I1
UniProt Synonym Gene Names
DNCI1; DNCIC1; DH IC-1
UniProt Entry Name
DC1I1_HUMAN
NCBI Protein Information
cytoplasmic dynein 1 intermediate chain 1; DH IC-1; dynein intermediate chain 1, cytosolic; cytoplasmic dynein intermediate chain 1; dynein, cytoplasmic, intermediate polypeptide 1

UniProt Comments for DYNC1I1

DYNC1I1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. Belongs to the dynein intermediate chain family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: kinetochore; spindle pole; microtubule; recycling endosome; cytoplasmic dynein complex; perinuclear region of cytoplasm; cytosol; vesicle

Molecular Function: protein binding; spectrin binding; microtubule binding; motor activity; microtubule motor activity

Biological Process: metabolic process; vesicle transport along microtubule; antigen processing and presentation of exogenous peptide antigen via MHC class II
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Research Articles on DYNC1I1

1. Genome sequencing of the deletion breakpoints showed that the DLX5 and DLX6 genes are disomic but the putative DYNC1I1 exon 15 and 17 enhancers are deleted.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DYNC1I1 antibody

 Reference Product  PubMed Publications
 DYNC1I2 antibody  >1 publications with DYNC1I1 and DYNC1I2
 DCTN1 antibody  >1 publications with DYNC1I1 and DCTN1
 DYNLL1 antibody  >1 publications with DYNC1I1 and DYNLL1

Pathways associated with anti-DYNC1I1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram

Diseases associated with anti-DYNC1I1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with DYNC1I1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >2 publications with DYNC1I1 and Congenital Abnormalities
 Peripheral Nervous System Diseases Antibodies  >2 publications with DYNC1I1 and Peripheral Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with DYNC1I1 and Carcinoma, Hepatocellular
 Multiple Myeloma Antibodies  >1 publications with DYNC1I1 and Multiple Myeloma

Organs/Tissues associated with anti-DYNC1I1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with DYNC1I1 and Brain
 Ovary Antibodies  >1 publications with DYNC1I1 and Ovary
 Skin Antibodies  >1 publications with DYNC1I1 and Skin
 Embryonic Tissue Antibodies  >1 publications with DYNC1I1 and Embryonic Tissue
 Bone Marrow Antibodies  >1 publications with DYNC1I1 and Bone Marrow
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