CEL Antibody – Rabbit Polyclonal

CEL: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8); also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerolipid; EC 3.1.1.13; Secreted, signal peptide; Secreted; Lipid Metabolism - steroid biosynthesis; Lipase; EC 3.1.1.3

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: sterol esterase activity; heparin binding; triacylglycerol lipase activity; protein binding; hydrolase activity; acylglycerol lipase activity; catalytic activity

Biological Process: intestinal lipid catabolic process; triacylglycerol metabolic process; cholesterol absorption; fatty acid catabolic process; lipid metabolic process; pancreatic juice secretion; protein amino acid esterification; cholesterol catabolic process; lipid digestion

Disease: Maturity-onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction