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ITPKB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129517
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The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number… More details

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Product Overview

Online Datasheet in PDF
Product Name
ITPKB, Polyclonal Antibody
Full Product Name
ITPKB Polyclonal Antibody
Product Gene Name
anti-ITPKB antibody
Product Synonym Names
IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
946
OMIM
147522
3D Structure
ModBase 3D Structure for P27987
Species
Human
Immunogen
Recombinant protein of human ITPKB
Calculated Molecular Weight
102kDa

Product Categories/Family for anti-ITPKB antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ITPKB antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ITPKB antibody
WB: 1:200-1:2000

Western Blot (WB) of anti-ITPKB antibody

Western blot analysis of extracts of various cell lines, using ITPKB antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
Rabbit Anti-ITPKB Polyclonal Antibody – Cat# MBS129517

Immunohistochemistry (IHC) of anti-ITPKB antibody

Immunohistochemistry of paraffin-embedded human liver injury using ITPKB antibody at dilution of 1:100 (40x lens).
Rabbit Anti-ITPKB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129517

Immunohistochemistry (IHC) of anti-ITPKB antibody

Immunohistochemistry of paraffin-embedded human stomach using ITPKB antibody at dilution of 1:100 (40x lens).
Rabbit Anti-ITPKB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129517

Immunohistochemistry (IHC) of anti-ITPKB antibody

Immunohistochemistry of paraffin-embedded rat kidney using ITPKB antibody at dilution of 1:100 (40x lens).
Rabbit Anti-ITPKB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129517

Immunohistochemistry (IHC) of anti-ITPKB antibody

Immunohistochemistry of paraffin-embedded mouse heart using ITPKB antibody at dilution of 1:100 (40x lens).
Rabbit Anti-ITPKB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129517

Other Notes

Small volumes of anti-ITPKB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITPKB purchase

MBS129517 is an antibody targeting ITPKB. Also known as ITPKB Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ITPKB. It may not necessarily be applicable to this product.

NCBI GI #
62906885
NCBI GeneID
3707
NCBI Accession #
P27987.5
UniProt Primary Accession #
P27987
UniProt Secondary Accession #
Q5VWL9; Q5VWM0; Q96BZ2; Q96JS1; Q9UH47
UniProt Related Accession #
P27987
NCBI Official Full Name
Inositol-trisphosphate 3-kinase B
NCBI Official Synonym Full Names
inositol-trisphosphate 3-kinase B
NCBI Official Symbol
ITPKB
NCBI Official Synonym Symbols
IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
UniProt Protein Name
Inositol-trisphosphate 3-kinase B
UniProt Synonym Protein Names
Inositol 1,4,5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B
Protein Family
Inositol-trisphosphate 3-kinase
UniProt Gene Name
ITPKB
UniProt Synonym Gene Names
IP3 3-kinase B; IP3K B; InsP 3-kinase B
UniProt Entry Name
IP3KB_HUMAN
NCBI Protein Information
inositol-trisphosphate 3-kinase B; IP3K B; IP3 3-kinase B; insP 3-kinase B; proliferation-inducing protein 37; inositol 1,4,5-trisphosphate 3-kinase B

UniProt Comments for ITPKB

ITPKB: The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

Protein type: EC 2.7.1.127; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: cytosol

Molecular Function: calmodulin binding; protein binding; inositol trisphosphate 3-kinase activity; ATP binding

Biological Process: cell surface receptor linked signal transduction; inositol phosphate metabolic process; MAPKKK cascade; positive regulation of Ras protein signal transduction; signal transduction; positive regulation of alpha-beta T cell differentiation; positive thymic T cell selection
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Research Articles on ITPKB

1. ITPKB is increased in Alzheimer's brain three-fold in the cerebral cortex of most patients with Alzheimer's disease compared with control subjects and accumulates in dystrophic neurites associated with amyloid plaques.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITPKB antibody

 Reference Product  PubMed Publications
 IPMK antibody  >2 publications with ITPKB and IPMK

Pathways associated with anti-ITPKB antibody

 Products by Pathway  Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram

Diseases associated with anti-ITPKB antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with ITPKB and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with ITPKB and Brain Diseases

Organs/Tissues associated with anti-ITPKB antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with ITPKB and Blood
 Brain Antibodies  >4 publications with ITPKB and Brain
 Bone Antibodies  >3 publications with ITPKB and Bone
 Bone Marrow Antibodies  >3 publications with ITPKB and Bone Marrow
 Uterus Antibodies  >1 publications with ITPKB and Uterus
 Embryonic Tissue Antibodies  >1 publications with ITPKB and Embryonic Tissue
 Nerve Antibodies  >1 publications with ITPKB and Nerve
 Skin Antibodies  >1 publications with ITPKB and Skin
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