Human ASCC3 Recombinant Protein – Cat# MBS1296651

Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3), Partial (ASCC3) Human Recombinant Protein

Name: ASCC3 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1296651
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1296651

3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and… More details

$575 / 0.02 mg (Baculovirus) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Activating signal cointegrator 1 complex subunit 3 (ASCC3), partial, Recombinant Protein

Full Product Name

Recombinant Human Activating signal cointegrator 1 complex subunit 3 (ASCC3), partial

Product Gene Name

ASCC3 recombinant protein

Product Synonym Gene Name

ASCC3; HELIC1

Product Synonym Names

Activating signal cointegrator 1 complex subunit 3; EC=3.6.4.12; ASC-1 complex subunit p200; ASC1p200; Helicase, ATP binding 1; Trip4 complex subunit p200

Sequence

MALPRLTGAL RSFSNVTKQD NYNEEVADLK IKRSKLHEQV LDLGLTWKKI IKFLNEKLEK SKMQSINEDL KDILHAAKQI EVNCPFQKRR LDGKEEDEKM SRASDRFRGL R

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

40 kDa

Sequence Positions

1-111aa; Full Length of Isoform 2

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

614217

3D Structure

ModBase 3D Structure for Q8N3C0

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ASCC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASCC3 purchase

MBS1296651 is a recombinant protein targeting ASCC3. Also known as Recombinant Human Activating signal cointegrator 1 complex subunit 3 (ASCC3), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ASCC3. It may not necessarily be applicable to this product.

NCBI GI #

546232111

NCBI GeneID

10973

NCBI Accession #

NP_001271200.1

UniProt Primary Accession #

Q8N3C0

UniProt Secondary Accession #

O43738; Q4G1A0; Q5VTN2; Q9H1I9; Q9H5A2; Q9NTR0; E7EW23

UniProt Related Accession #

Q8N3C0

GenBank Nucleotide #

NM_001284271.1

NCBI Official Full Name

activating signal cointegrator 1 complex subunit 3 isoform c

NCBI Official Synonym Full Names

activating signal cointegrator 1 complex subunit 3

NCBI Official Symbol

ASCC3

NCBI Official Synonym Symbols

RNAH; HELIC1; ASC1p200

UniProt Protein Name

Activating signal cointegrator 1 complex subunit 3

UniProt Synonym Protein Names

ASC-1 complex subunit p200; ASC1p200; Helicase, ATP binding 1; Trip4 complex subunit p200

Protein Family

Activating signal cointegrator 1 complex

UniProt Gene Name

ASCC3

UniProt Synonym Gene Names

HELIC1; ASC1p200

UniProt Entry Name

ASCC3_HUMAN

NCBI Protein Information

activating signal cointegrator 1 complex subunit 3; RNA helicase family; helicase, ATP binding 1; ASC-1 complex subunit P200; trip4 complex subunit p200

NCBI Summary for ASCC3

This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

UniProt Comments for ASCC3

ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; Transcription, coactivator/corepressor; Helicase

Chromosomal Location of Human Ortholog: 6q16

Cellular Component: Golgi apparatus; membrane; cytoplasm; intracellular; nucleus

Molecular Function: protein binding; ATP-dependent 3'-5' DNA helicase activity; ATP binding

Biological Process: cell proliferation; DNA dealkylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA duplex unwinding

Research Articles on ASCC3

1. Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.