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Tectonic-1 (TCTN1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1305433

This gene encodes a member of the tectonic family of secreted and transmembrane proteins. The orthologous gene in mouse is required for formation of most ventral cell types. It functions downstream of smoothened and rab23 to modulate hedgehog signal… More details

$1360 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tectonic-1 (TCTN1), Recombinant Protein
Full Product Name
Recombinant Human Tectonic-1 (TCTN1)
Product Gene Name
TCTN1 recombinant protein
Product Synonym Gene Name
TCTN1
Sequence
QTDATPAVTT EGLNSTEAAL ATFGTFPSTR PPGTPRAPGP SSGPRPTPVT DVAVLCVCDL SPAQCDINCC CDPDCSSVDF SVFSACSVPV VTGDSQFCSQ KAVIYSLNFT ANPPQRVFEL VDQINPSIFC IHITNYKPAL SFINPEVPDE NNFDTLMKTS DGFTLNAESY VSFTTKLDIP TAAKYEYGVP LQTSDSFLRF PSSLTSSLCT DNNPAAFLVN QAVKCTRKIN LEQCEEIEAL SMAFYSSPEI LRVPDSRKKV PITVQSIVIQ SLNKTLTRRE DTDVLQPTLV NAGHFSLCVN VVLEVKYSLT YTDAGEVTKA DLSFVLGTVS SVVVPLQQKF EIHFLQENTQ PVPLSGNPGY VVGLPLAAGF QPHKGSGIIQ TTNRYGQLTI LHSTTEQDCL ALEGVRTPVL FGYTMQSGCK LRLTGALPCQ LVAQKVKSLL WGQGFPDYVA PFGNSQAQDM LDWVPIHFIT QSFNRKDSCQ LPGALVIEVK WTKYGSLLNP QAKIVNVTAN LISSSFPEAN SGNERTILIS TAVTFVDVSA PAEAGFRAPP AINARLPFNF FFPFV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
28,532 Da
Sequence Positions
23-587, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
609863
3D Structure
ModBase 3D Structure for Q2MV58
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TCTN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TCTN1 purchase

MBS1305433 is a recombinant protein targeting TCTN1. Also known as Recombinant Human Tectonic-1 (TCTN1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TCTN1. It may not necessarily be applicable to this product.

NCBI GI #
130978357
NCBI GeneID
79600
NCBI Accession #
NP_001076006.1
UniProt Primary Accession #
Q2MV58
UniProt Secondary Accession #
Q49A60; Q6P5X1; Q6UXW2; Q8NAE9; Q96N72; Q9H798; A8MX11
UniProt Related Accession #
Q2MV58
GenBank Nucleotide #
NM_001082537.2
NCBI Official Full Name
tectonic-1 isoform 2
NCBI Official Synonym Full Names
tectonic family member 1
NCBI Official Symbol
TCTN1
NCBI Official Synonym Symbols
TECT1; JBTS13
UniProt Protein Name
Tectonic-1
Protein Family
Tectonic
UniProt Gene Name
TCTN1
UniProt Synonym Gene Names
TECT1
NCBI Protein Information
tectonic-1

NCBI Summary for TCTN1

This gene encodes a member of a family of secreted and transmembrane proteins. The orthologous gene in mouse functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. This protein is a component of the tectonic-like complex, which forms a barrier between the ciliary axoneme and the basal body. A mutation in this gene was found in a family with Joubert syndrome-13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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UniProt Comments for TCTN1

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 ().
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Research Articles on TCTN1

1. we describe the phenotype of a patient with Varadi syndrome who is homozygous for a previously reported mutation in TCTN1 (NM_001082538.2:c.342-2A>G, p.Gly115Lysfs*8) and suggest that allelic disorders linked to TCTN1 include Varadi syndrome, in addition to Joubert syndrome and Meckel-Gruber syndrome.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TCTN1 recombinant protein

 Reference Product  PubMed Publications
 TCTN2 recombinant protein  >4 publications with TCTN1 and TCTN2
 CEP290 recombinant protein  >3 publications with TCTN1 and CEP290
 AHI1 recombinant protein  >2 publications with TCTN1 and AHI1
 TMEM67 recombinant protein  >2 publications with TCTN1 and TMEM67
 TMEM216 recombinant protein  >2 publications with TCTN1 and TMEM216
 CC2D2A recombinant protein  >2 publications with TCTN1 and CC2D2A
 TMEM231 recombinant protein  >1 publications with TCTN1 and TMEM231
 MKS1 recombinant protein  >1 publications with TCTN1 and MKS1
 B9D1 recombinant protein  >1 publications with TCTN1 and B9D1

Diseases associated with TCTN1 recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >1 publications with TCTN1 and Brain Diseases
 Neural Tube Defects Antibodies  >1 publications with TCTN1 and Neural Tube Defects
 Kidney Diseases Antibodies  >1 publications with TCTN1 and Kidney Diseases
 Nervous System Diseases Antibodies  >1 publications with TCTN1 and Nervous System Diseases
 Joubert syndrome 1 Antibodies  >1 publications with TCTN1 and Joubert syndrome 1

Organs/Tissues associated with TCTN1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with TCTN1 and Eye
 Kidney Antibodies  >2 publications with TCTN1 and Kidney
 Liver Antibodies  >1 publications with TCTN1 and Liver
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