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APOBEC1 Complementation Factor (A1CF) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1314019

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three… More details

$1390 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
APOBEC1 complementation factor (A1cf), Recombinant Protein
Full Product Name
Recombinant Mouse APOBEC1 complementation factor (A1cf)
Product Gene Name
A1cf recombinant protein
Product Synonym Gene Name
A1cf
Sequence
MESNHKSGDG LSGTQKEAAL RALVQRTGYS LVQENGQRKY GGPPPGWDST PPERGCEIFI GKLPRDLFED ELIPLCEKIG KIYEMRLMMD FNGNNRGYAF VTFSNKQEAK NAIKQLNNYE IRTGRLLGVC ASVDNCRLFV GGIPKTKKRE EILSEMKKVT EGVVDVIVYP SAADKTKNRG FAFVEYESHR AAAMARRRLL PGRIQLWGHP IAVDWAEPEV EVDEDTMSSV KILYVRNLML STSEEMIEKE FNSIKPGAVE RVKKIRDYAF VHFSNREDAV EAMKALNGKV LDGSPIEVTL AKPVDKDSYV RYTRGTGGRN TMLQGEYTYP LSHVYDPTTT YLGAPVFYTP QAYAAIPSLH FPATKGHLSN RALIRTPSVR EIYMNVPVGA AGVRGLGGRG YLAYTGLGRG YHVKGDKRED KLYDLLPGME LTPMNTVSLK PQGIKLAPQI LEEICQKNNW GQPVYQLHSA IGQDQRQLFL YKVTIPALAS QNPAIHPFIP PKLSAYVDEA KRYAAEHTLQ TLGIPTEGGD AGTTAPTATS ATVFPGYAVP SATAPVSTAQ LKQAVTLGQD LAAYTTYEVY PTFALTTRGD AYGTF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
42,996 Da
Sequence Positions
1-595, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q5YD48
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of A1cf recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A1cf purchase

MBS1314019 is a recombinant protein targeting A1cf. Also known as Recombinant Mouse APOBEC1 complementation factor (A1cf). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for A1cf. It may not necessarily be applicable to this product.

NCBI GI #
124487289
NCBI GeneID
69865
NCBI Accession #
NP_001074543.1
UniProt Primary Accession #
Q5YD48
UniProt Secondary Accession #
Q5FW55; Q5YD47; E9QJS8
UniProt Related Accession #
Q5YD48
GenBank Nucleotide #
NM_001081074.1
NCBI Official Full Name
APOBEC1 complementation factor
NCBI Official Synonym Full Names
APOBEC1 complementation factor
NCBI Official Symbol
A1cf
NCBI Official Synonym Symbols
ASP; Acf; MCM; mer; ACF64; ACF65; MerCreMer; 1810073H04Rik; Tg(Myh6-cre/Esr1*)1Jmk
UniProt Protein Name
APOBEC1 complementation factor
UniProt Synonym Protein Names
APOBEC1-stimulating protein
Protein Family
APOBEC1 complementation factor
UniProt Gene Name
A1cf
NCBI Protein Information
APOBEC1 complementation factor

UniProt Comments for A1cf

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay ().
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Research Articles on A1cf

1. Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with A1cf recombinant protein

 Products by Pathway  Pathway Diagram
 Formation Of The Editosome Pathway antibodies  Formation Of The Editosome Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 MRNA Editing Pathway antibodies  MRNA Editing Pathway Diagram
 MRNA Editing: C To U Conversion Pathway antibodies  MRNA Editing: C To U Conversion Pathway Diagram

Diseases associated with A1cf recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with A1cf and Kidney Diseases
 Liver Diseases Antibodies  >1 publications with A1cf and Liver Diseases

Organs/Tissues associated with A1cf recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with A1cf and Liver
 Intestine Antibodies  >3 publications with A1cf and Intestine
 Kidney Antibodies  >3 publications with A1cf and Kidney
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